Influence of the H2-receptor blocking agent metiamide on the clonidine-induced changes in the brain catecholamine turnover |
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Authors: | N -E Andén Maria Grabowska-Andén |
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Institution: | (1) Present address: Department of Medical Pharmacology, Biomedicum, University of Uppsala, Uppsala, Sweden |
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Abstract: | Summary Metiamide (800 g intracerebroventricularly to rats) enhanced the DOPA accumulation in noradrenaline-predominant brain areas following DOPA decarboxylase inhibition and it accelerated the -methyltyrosine-induced disappearance of noradrenaline in the brain, both normally and after clonidine (0.1 mg/kg i.p.). These findings indicate that metiamide stimulates the release of noradrenaline. They can explain why metiamide antagonizes the clonidine-induced hypotension. |
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