| CFH、ARMS2、HTRA1与年龄相关性黄斑病变的相关性研究进展 |
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| 引用本文： | 杨云荔,陈浩宇.CFH、ARMS2、HTRA1与年龄相关性黄斑病变的相关性研究进展[J].医学综述,2012(18):2954-2956. |
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| 作者姓名： | 杨云荔 陈浩宇 |
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| 作者单位： | 汕头大学·香港中文大学联合汕头国际眼科中心 |
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| 摘 要： | 年龄相关性黄斑病变(ARM)是一种慢性进展性疾病,可分为早期阶段和晚期阶段。近年来,国内外开展了补体因子H(CFH)、年龄相关性黄斑变性易患位点2(ARMS2)、高温必需蛋白A1(HTRA1)的单核苷酸多态性与早期ARM及晚期ARM(又称年龄相关性黄斑变性)的相关性研究,对ARM的遗传学研究取得了一定进展。现对CFH、ARMS2、HTRA1与ARM的相关性研究进行综述。
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| 关 键 词： | 年龄相关性黄斑病变 发病机制 分子遗传学 基因 |
Research Progress in Correlation between CFH,ARMS2,HTRA1 and Age-related Maculopathy |
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| YANG Yun-li,CHEN Hao-yu.Research Progress in Correlation between CFH,ARMS2,HTRA1 and Age-related Maculopathy[J].Medical Recapitulate,2012(18):2954-2956. |
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| Authors: | YANG Yun-li CHEN Hao-yu |
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| Institution: | .(Joint Shantou International Eye Center,Shantou University and the Chinese University of Hong Kong,Shantou 515041,China) |
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| Abstract: | Age-related maculopathy(ARM)as a progressive disease can been divided into early stage and late stage.Recently,a number of studies investigated the correlation between the polymorphism of complement factor H(CFH),age-related maculopathy susceptibility2(ARMS2),high temperature reguiremet A1(HTRA1)and early ARM or advanced ARM.Here is to make a review on recent studies of research progress on the correlation between CFH,ARMS2,HTRA1 and ARM. |
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| Keywords: | Age-related maculopathy Pathogenesis Molecular genetics Gene |
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