The effects of zimeldine and alaproclate combined with a small dose of 5-HTP on waking and sleep stages in cats |
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| Authors: | L Sommerfelt R Ursin |
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| Institution: | 1. Center for Chinese Medicine Therapy and Systems Biology, Institute for Interdisciplinary Medicine Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;2. School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;3. Experiment Center of Teaching & Learning, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;4. Department of Physiology, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;5. Shanghai Innovation Center of TCM Health Service, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;6. The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines and the State Administration of Traditional Chinese Medicine (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China;1. Inland Waters Aquatics Resources Research Center, Iranian Fisheries Sciences Research Institute, Agricultural Research, Education and Extension Organization, Gorgan, Iran;2. Department of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran;3. Department of Aquatic Animal Health, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran;4. Department of Fisheries, Faculty of Fisheries and Environmental Sciences, Gorgan University of Agricultural Sciences and Natural Resources, Gorgan, Iran;5. Department of Animal and Aquatic Sciences, Faculty of Agriculture, Chiang Mai University, Chiang Mai 50200, Thailand;6. Science and Technology Research Institute, Chiang Mai University, 239 Huay Keaw Rd., Suthep, Muang, Chiang Mai 50200, Thailand;1. Kim Ross is the School of Nutrition Division Director, an Assistant Professor at Southwest College of Naturopathic Medicine & Health Sciences;2. Mary VanNortwick is Director of Nutrition and Wellness at Mary Baldwin University |
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| Abstract: | Sleep and waking stages in cats were studied 8 h following administration of zimeldine and alaproclate, in combination with saline or 5-hydroxy-1-tryptophan (5-HTP). Both drugs in combination with saline reduced rapid eye movement sleep and ponto-geniculo-occipital wave activity, and the effects were potentiated with 5-HTP. After administration of zimeldine in combination with 5-HTP there was an increase in synchronized waking (W-2), followed by an increase in slow wave sleep (SWS), at first SWS-1 with spindles and then highly synchronized SWS-2. The changes were interpreted as reflecting a serotonergic deactivating effect expressed by an electroencephalographic synchronizing effect. This is consistent with earlier studies following serotonin depletion and serotonin precursor loading. After alaproclate in combination with 5-HTP there were changes in W-2 and SWS-1 suggestive of the same process but much less pronounced. The difference between the two serotonin uptake inhibitors is interpreted as being due to regional differences in their uptake inhibition. |
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