缬沙坦对冠心病患者脂联素和血管内皮功能的影响

目的探讨缬沙坦对冠心病患者脂联素和血管内皮功能的影响。方法将40例冠心病患者随机分为2组,常规治疗组20例给予阿司匹林和酒石酸美托洛尔(倍他乐克),缬沙坦组20例给予常规治疗加缬沙坦。治疗前和治疗8周后,采用超声多普勒法测定血流介导的肱动脉舒张反应(FMD),并检测治疗前后患者血浆脂联素水平和一氧化氮(NO)水平。结果与治疗前比较,常规治疗组肱动脉基础内径、FMD、NO、脂联素水平均无显著变化(P>0.05),缬沙坦组除肱动脉基础内径外,其余指标均显著升高(P<0.05,P<0.01)。与常规治疗组相比,缬沙坦组治疗后FMD、脂联素、NO水平均明显增加(P<0.05,P<0.01)。2组治疗前后血压水平均无明显变化。FMD与脂联素水平(β=0.308,P<0.05)和NO水平(β=0.417,P<0.05)均呈正相关。结论缬沙坦可能通过增加冠心病患者血浆中脂联素水平改善血管内皮功能。

The effect of valsartan on adiponectin and vascular endothelial function in coronary artery disease

Objective To investigate the effects of valsaitan on adiponectin and endothelial function in patients with coronary heart disease.Methods Forty patients were randomly divided into 2 groups,the conventional treatment group of 20 cases treated with aspirin and tartaric acid metoprolol（Betaloc）,valsaitan group of 20 cases were given conventional treatment and valsartan.Before and 8 weeks after treatment,ulfeasonic Doppler examination were performed for the determination of brachial artery flow mediated vasodilation（FMD） before and after treatment,and patients＇ plasma adiponectin levels and nitric oxide（NO） level.Results Compared with before treatment,the conventional treatment group of the brachial artery diameter,FMD,NO,adiponectin level had no significant changes（P〉0.05）,valsartan group except brachial arteries,other indexes were significantly elevated（P〈 0.05,P〈 0.01）.Compared with the conventional treatment group,after treatment,valsartan groups FMD,adiponectin,NO levels were significantly increased（P 〈0.05,P〈 0.01）.Before and after treatment,blood pressure levels in the 2 groups had no obvious change.FMD and adiponectin levels（3=0.308,P 〈 0.05） and NO（B =0.417,P 〈0.05） were positively correlated.Conclusion Hie valsartan could improve endothelial function in patients with coronary heart disease by increasing adiponectin levels.