|
|||||
|
|
Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA |
|
| Authors: | Zhao Long-Xuan Park Jae Gyu Moon Yoon-Soo Basnet Arjun Choi Jongwon Kim Eun-Kyung Jeong Tae Cheon Jahng Yurngdong Lee Eung-Seok |
| Affiliation: | Department of Chemistry, Liaoning Normal University, Dalian, Liaoning 116-029, P.R.China. |
| Abstract: | For the development of new anticonvulsive agents, analogs of gamma-vinyl GABA (vigabatrin) containing GABA, gamma-vinyl GABA, valproic acid, nipecotic acid or isonipecotic acid moieties were prepared and evaluated for their anticonvulsive activities. Most of the prepared compounds showed moderate anticonvulsive activities. Among them compounds 10 and 16 displayed the most potent anticonvulsive activity and a broader spectrum compared to vigabatrin. |
| Keywords: | Vigabatrin γ-vinyl GABA Anticonvulsive activity GABA Synthesis |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ | |