狼疮性BXSB小鼠抗DNA抗体水平的动态变化

目的 探讨系统性红斑狼疮性小鼠抗ＤＮＡ抗体水平的动态变化与疾病严重程度之间的关系。方法 测定了不同月龄的狼疮性ＢＸＳＢ小鼠的各种抗ＤＮＡ抗体、血尿素氮和尿蛋白质浓度。结果 ＢＸＳＢ小鼠抗ＤＮＡ抗体量的动态变化无规律性，但血尿素氮和尿蛋白质的浓度随鼠龄的增加而逐步升高。结论抗ＤＮＡ抗体水平并不与ＢＸＳＢ小鼠疾病的严重程度相平行，提示在诊断ＳＬＥ或判断其严重程度时应测定多实验指标为宜。

Kinetics of anti-DNA antibody appearance in lupus-prone BXSB mice

Objective It remains unknown whether there is a correlation between the level of anti DNA antibodies and pathological severity in SLE mice.MethodsAnti DNA IgG and IgM antibodies, blood BUN and urine protein in lupus prone BXSB mice with age varying from 1 to 6 month were detected quantitatively in our experiment.ResultsWe found that anti DNA antibodies in serum varied irregularly while the concentration of blood BUN and urine protein increased gradually with age.ConclusionThat the level of anti DNA antibodies do not parallel the pathological severity in BXSB mice and it be necessary to survey multiple different items for diagnosing SLE or determining its seriousness. [