无抽搐电休克治疗难治性精神分裂症临床研究

目的 探讨无抽搐电休克治疗(Modified electroconvulsive therapy,MECT)对难治性精神分裂症(Treatment-refractorv schizophrenia,TRS)的疗效及不良反应.方法 对40例难治性精神分裂症患者在原服用抗精神病药物的基础上合并无抽搐电休克治疗,分别于治疗前及治疗后使用阳性与阴性症状量表(PANSS)、副反应量表(TESS)和韦氏记忆量表(WMS)评定两组患者的疗效及不良反应.结果 合并无抽搐电休克治疗后PANSS评分明显降低(t=2.04,3.22,3.55;P＜0.05或0.01),WMS在治疗第1天末较治疗前显著下降(t=2.42,2.06,2.23,2.56;P＜0.05),但1周、2周末与治疗前无显著性差异(P＞0.05).结论 无抽搐电休克治疗难治性精神分裂症疗效显著,不良反应少.

Clinical Study of Modified Electroconvulsive Therapy in Treatment-refractory Schizophrenia

Objective To understand the efficacy and side effects of modified electroconvulsive therapy(MECT)in treatment-refractory schizophrenia(TRS).Methods A total of 40 TRS patients who had received antipsychotics medication were assigned to receive MECT,and the Positive and Negative Syndrome Scale(PANSS),Wechsler Memory Scale(WMS) and Treatment Emergent Symptoms Scale(TESS) were used before and after treatment.Results The PANSS scores significantly decreased after MECT(t=2.04,3.22,3.55;P<0.05 or 0.01).The WMS sco...