<Emphasis Type="Italic">Helicobacter bilis</Emphasis>-Associated Suppurative Cholangitis in a Patient with X-Linked Agammaglobulinemia |
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| Authors: | Nicolas Degand Justine Dautremer Benoît Pilmis Agnès Ferroni Fanny Lanternier Julie Bruneau Olivier Hermine Stéphane Blanche Xavier Nassif Olivier Lortholary Marc Lecuit |
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| Institution: | 1.Université Paris Descartes - Sorbonne Paris Cité, Laboratoire de Microbiologie, H?pital Necker-Enfants Malades, Assistance Publique - H?pitaux de Paris,Paris,France;2.CHU de Nice, Laboratoire de Bactériologie,Nice,France;3.Université Paris Descartes - Sorbonne Paris Cité, Service de Maladies infectieuses et Tropicales, H?pital Necker-Enfants Malades, Centre d’Infectiologie Necker-Pasteur, Assistance Publique - H?pitaux de Paris,Paris,France;4.Université Paris Descartes - Sorbonne Paris Cité, Service d’Anatomopathologie, H?pital Necker-Enfants Malades, Assistance Publique - H?pitaux de Paris,Paris,France;5.Université Paris Descartes - Sorbonne Paris Cité, Service d’Hématologie, H?pital Necker-Enfants Malades, Assistance Publique - H?pitaux de Paris,Paris,France;6.Université Paris Descartes - Sorbonne Paris Cité, Service d’Immuno-hématologie pédiatrique, H?pital Necker-Enfants Malades, Assistance Publique - H?pitaux de Paris,Paris,France |
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| Abstract: | ? Helicobacter bilis is a commensal bacterium causing chronic hepatitis and colitis in mice. In humans, enterohepatic Helicobacter spp. are associated with chronic hepatobiliary diseases.PurposeWe aimed at understanding the microbial etiology in a patient with X-linked agammaglobulinemia presenting with suppurative cholangitis.Methods16S rDNA PCR directly performed on a liver biopsy retrieved DNA of H. bilis.ResultsClinical outcome resulted in the normalization of clinical and biological parameters under antibiotic treatment by a combination of ceftriaxone, metronidazole, and doxycyclin followed by a 2-week treatment with moxifloxacin and a 2-month treatment with azithromycin.ConclusionIn conclusion, these data suggest a specific clinical and microbiological approach in patients with humoral deficiency in order to detect H. bilis hepatobiliary diseases. |
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