Mechanism of ulcerogenic activity of reserpine in albino rats |
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| Authors: | M B Gupta K K Tangri K P Bhargava |
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| Affiliation: | Department of Pharmacology and Therapeutics, King George''s Medical College, Lucknow, India |
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| Abstract: | Reserpine-induced gastric ulceration was significantly prevented by α-adrenoceptor blockers but not by propanolol or by bilateral adrenalectomy. Intracerebroventricular (i.c.v.) administration of reserpine as well as tetrabenazine failed to induce ulceration in albino rats. Pretreatment with 6-hydroxydopamine or atropine methyl nitrate protected the animals from the ulcerogenic activity of reserpine. |
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| Keywords: | Gastric ulcer Reserpine |
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