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对充血性心力衰竭患者血浆ANP、NO的影响
引用本文:王瑞娟,茅惠明,张芬. 对充血性心力衰竭患者血浆ANP、NO的影响[J]. 上海中医药杂志, 1999, 0(6)
作者姓名:王瑞娟  茅惠明  张芬
作者单位:上海市东方医院
摘    要:采用静脉滴注复方丹参、黄芪注射液治疗30例充血性心力衰竭(CHF),另设正常对照组30例,以观察其对CHF患者血浆心纳素(ANP)、一氧化氮(NO)、内皮素(ET)、降钙素相关基因肽(CGRP)浓度的影响。结果:治疗组治疗2周后,ANP显著降低(P<001),NO明显上升(P<005),且接近正常组水平(P>005),ET、CGRP治疗前后与正常组无显著差异(P>005);心功能较治疗前普遍改善1级。提示复方丹参、黄芪注射液能改善CHF患者血管内皮细胞功能,促进NO的释放。

关 键 词:充血性心力衰竭(CHF)  复方丹参注射液  黄芪注射液  心钠素(ANP)  一氧化氮(NO)

InfluenceofCompoundSalviaInjectionandAstraglusInjectiontoPlasmaANPandNOinthePatientswithCongestiveHeartFailure
ShanghaiDongfangHospital WANGRuijuanX) MAOHuimingX) ZHANGFen. InfluenceofCompoundSalviaInjectionandAstraglusInjectiontoPlasmaANPandNOinthePatientswithCongestiveHeartFailure[J]. Shanghai Journal of Traditional Chinese Medicine, 1999, 0(6)
Authors:ShanghaiDongfangHospital WANGRuijuanX) MAOHuimingX) ZHANGFen
Abstract:casesofcongestiveheartfailure(CHF)weretreatedbyintravenousperfusionofCompoundSalviaInjectionandAstraglusInjection,togetherwithanothernormal30casesasthecontrolgroup,toobservetheirinfluencetoconcentrationofplasmaAnorprogesterone(ANP),nitrousoxide(NO),endotheliolysin(ET)andcalcitoningenerelatedpeptide(CGRP).Theresultsshowedthatinthetreatmentgroup,aftertwoweeksofthetreatments,ANPdecreasedremarkably(P<0.01)andNOincreasedobviously(P<0.05),closetothelevelofthenormalgroup(P>0.05),thattherewasnosignificantdifference(P>0.05)inETandCGRPbeforeandaftertreatmentsincomparisonofthenormalgroupandthatthecardiacfunctionswereimprovedonegradegenerallythanthatbeforethetreatments.TheseresultsindicatethatCompoundSalviaInjectionandAstraglusInjectioncanimprovethefunctionofvascularendothelialcellandpromoteNOreleaseinCHFpatients.
Keywords:Congestiveheartfailure  CompoundSalviaInjection  AstraglusInjection  Anorprogesterone(ANP)  nitrousoxide(NO)  
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