| 慢性应激引起的大鼠海马神经细胞形态结构的改变 |
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| 引用本文： | 林志雄,殷静雯,罗旭东.慢性应激引起的大鼠海马神经细胞形态结构的改变[J].广州医学院学报,2014(3):14-16. |
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| 作者姓名： | 林志雄 殷静雯 罗旭东 |
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| 作者单位： | 广东医学院附属医院精神心理科,广东 湛江,524001 |
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| 摘 要： | 目的：探讨慢性应激引起的抑郁样行为与海马神经细胞形态结构的变化。方法：建立慢性轻度不可预见性应激大鼠抑郁模型，检测大鼠快感缺乏，行为活动减少，体质量减轻等抑郁样症状，观察海马区病理改变。结果：实验组和对照组大鼠行为学评分存在显著差异（P〈0.01），实验组海马椎体细胞萎缩，神经细胞层数减少，细胞数目明显减少（P〈0.01）。结论：应激可导致大鼠抑郁样行为的发生，同时影响神经细胞的生长和存活。
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| 关 键 词： | 抑郁障碍 慢性轻度不可预见性抑郁模型 海马 |
The pathological change in the neurons of hippocampus of rat after chronic unpredictable mild stress |
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| Lin Zhixiong,Yin Jingwen,Luo Xudong.The pathological change in the neurons of hippocampus of rat after chronic unpredictable mild stress[J].Academic Journal of Guangzhou Medical College,2014(3):14-16. |
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| Authors: | Lin Zhixiong Yin Jingwen Luo Xudong |
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| Institution: | (Affiliated Hospital of Guangdong Medical College,Zhanjiang, Guangdong 524001 ,China) |
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| Abstract: | Objective：To identify The Change in the neurons of Hippocampus of Rat and depressive-like behavior after Chronic Unpredictable Mild Stress （ CUMS）. Method： The mice were subjected to various unpredictable stressors during the 21 days CUMS procedures. The depressive-like behavior and pathological change was observed.Results：The number of neurons of hippocampus after stress was significantly different （P〈0.01）. Conclusion： Rats after chronic unpredictable mild stress appeared depressive-like behavior correlated with decreased of neurons hippocampus. |
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| Keywords: | depressive disorder CUMS hippocampus |
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