高迁移率族蛋白 B-1在尘肺患者的表达及意义

目的：通过监测尘肺患者血清高迁移率族蛋白-1（HMGB-1）的水平变化，初步探讨其在尘肺患者表达的临床意义及其机制。方法：选取在茂名市职业病防治院确诊为尘肺的患者42例，分别监测患者入院后6、12、24、48、72 h 血清 HMGB-1的水平变化，同时在上述时相点监测血清 TNF-α水平。选取同期20例正常人作为健康对照组。结果：尘肺患者血清 HMGB-1、TNF-α水平均显著高于健康对照组（P〈0.05），尘肺患者血清 HMGB-1的表达水平升高延续数天，48 h 达到高峰，其升高水平与 TNF-α水平呈正相关（P〈0.05）。结论：血清 HMGB-1在尘肺患者呈高度表达，且持续时间较长，其可作为尘肺肺损伤诊断的可靠指标。

High mobility group protein B-1 in the expression of pneumoconiosis patients and its clinical significance

Objective：By monitoring the pneumoconiosis patients serum high mobility protein 1 （HMGB-1） the level of change,and discussed its clinical significance in patients with pneumoconiosis expression and its mechanism. Methods Select the hospital diagnosed with 42 cases of pneumoconiosis patients, respectively, monitoring patients admitted to hospital after 6 h,12 h,24 h,48 h,72 h the levels of serum HMGB-1 change,at the same time with the same point in time monitoring the level of serum TNF alpha,normal people selected from our hospital medical center 20 cases of healthy controls. Results Pneumoconiosis patients HMGB - 1,serum TNF alpha levels were significantly higher than that of healthy controls （ P 〈 0. 05）, the expression levels of pneumoconiosis patients serum HMGB-1 continue for several days,48 h peak,the higher level and the level of TNF alpha were positively correlated. Conclusion Is highly expressed in pneumoconiosis patients serum HMGB-1,and the duration is longer,it can be used as a reliable indicator for diagnosis of pneumoconiosis lung injury.