增生性玻璃体视网膜病变眼玻璃体中白细胞介素、肿瘤坏死因子含量变化及意义

】　Objective　Todetermine the concentration of interleukin-12(IL-12),interleukin-2(IL-2) and tumornecrosis factor(TNF)and their possible role in the pathogenesis of proliferativevitreoretinopathy(PVR) ．　Methods　Patients were divided into 3 groups18 with PVR,7with simples retinal detachment caused by macular hole and 4 samples from normal eyes wereused as control.Samples of vitreous were obtained by aspiration through pars plana beforecryotherapy,vitrectomy and gas injection and stored in liquid nitrogen at －70℃ within30 minites for ELISA.　Results　 ①The levels of IL-12,IL-2，and TNF in the vitreousof PVR were positively correlated with the degree of severity of disease.②The levels ofIL-12,IL-2,and TNF in the PVR were higher than those in simple retinal detachment causedby macular hole and those in control group(P＜0.01).③The levels of IL-12,IL-2，and TNFin retinal detachment caused by macular hole were also higher than those in the controlgroup(P＜0.01).　Conclusion　IL-12,IL-2，and TNF may play a role at lease to someextent in the pathogenesis of PVR.

A assay of IL12,IL2,and TNF levels in the vitreous of patients with proliferative vitreoretinopathy