| 丙戊酸钠对大鼠脑NMDA受体在爪蟾卵母细胞表达的影响 |
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| 引用本文： | 顾饶胜,陈厚昌. 丙戊酸钠对大鼠脑NMDA受体在爪蟾卵母细胞表达的影响[J]. 吉林大学学报(医学版), 2003, 29(6): 733-735 |
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| 作者姓名： | 顾饶胜 陈厚昌 |
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| 作者单位： | 1. 第四军医大学吉林军医学院药理学教研室,吉林,吉林,132013
2. 第一军医大学药理学教研室 |
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| 基金项目： | 国家自然科学基金;39570827; |
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| 摘 要： | 目的 :观察丙戊酸钠对大鼠脑 N-甲基 - D-天冬氨酸 ( NMDA)受体在非洲爪蟾卵母细胞表达的影响。方法 :采用电压钳位技术记录表达于非洲爪蟾卵母细胞膜上的大鼠脑 NMDA受体通道电流及特性并观察 0 .1和 0 .5 mmol· L-1 丙戊酸钠对大鼠脑 NMDA受体通道电流的影响。结果 :丙戊酸钠 ( 0 .1和 0 .5 mmol· L-1 )对表达于非洲爪蟾卵母细胞的大鼠脑 NMDA受体功能有抑制作用 ,电流峰值由 ( 97.5± 9.8) n A降至 ( 79.7± 1 0 .5 ) n A、( 61 .3± 1 2 .5 ) n A ( P<0 .0 5和P<0 .0 1 )。结论 :丙戊酸钠对大鼠脑 NMDA受体有明显的抑制作用
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| 关 键 词： | 丙戊酸 受体,N-甲基-D-天冬氨酸 大鼠,Wistar 卵母细胞 爪蟾属 |
| 文章编号： | 1671-587X(2003)06-0733-03 |
| 修稿时间： | 2002-08-22 |
Effect of Sodium Valproate on the Expression of N-methyl-D-Aspartate Receptor of Rat Brain Tissue in Xenopus Oocytes |
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| GU Rao sheng ,CHEN Hou chang. Effect of Sodium Valproate on the Expression of N-methyl-D-Aspartate Receptor of Rat Brain Tissue in Xenopus Oocytes[J]. Journal of Jilin University: Med Ed, 2003, 29(6): 733-735 |
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| Authors: | GU Rao sheng CHEN Hou chang |
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| Affiliation: | GU Rao sheng 1,CHEN Hou chang 2 |
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| Abstract: | Objective:To observe the effect of valproate sodium on the expression of N methyl D aspartate(NMDA)receptor of rat brain tissue in xenopus. Methods:The currents of expressed receptors of NMDA in Xenopus oocytes were detected with the double electrode voltage clamps technique, and the effects of valproate sodium of 0.1,0.5 mmol·L -1 on them were obseved.Results:Valproate sodium inhibited markedly the current of NMDA receptor. The currents decreased from (97.5±9.8)nA to (79.7± 10.5) and (61.3±12.5)nA ( P <0.05 and P <0.01).Conclusion:Valproate sodium inhibites markedly the functions of NMDA receptor of Wistar rats brain. |
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| Keywords: | Valproic acid Receptors N methyl D aspartate Rats Wistar Oocytes Xenopus |
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