眼镜蛇毒因子激活补体对大鼠外周血白细胞数目和功能的影响 |
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引用本文: | 叶春玲,曹艳英,漆松涛.眼镜蛇毒因子激活补体对大鼠外周血白细胞数目和功能的影响[J].中国药理学通报,1997,13(6):520-521. |
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作者姓名: | 叶春玲 曹艳英 漆松涛 |
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作者单位: | 暨南大学医学院药理学教研室(叶春玲),暨南大学组织移植与免疫中心(曹艳英),第一军医大学南方医院(漆松涛) |
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基金项目: | 国务院侨办重点学科科研基金 |
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摘 要: | 目的:观察眼镜蛇毒因子(CVF)激活补体对大鼠外周血白细胞数目和功能的影响。方法:采用吞噬金葡菌法、玻璃血球计数板法分析测定白细胞的吞噬和粘附功能。结果:CVF1.0mg·kg-1ip,能使外周血白细胞吞噬和粘附功能显著升高,白细胞的吞噬率从20.7%±4.9%上升至42.5%±5.5%,粘附率从73.4%±8.3%上升至93.6%±9.8%;同时外周血白细胞数目短暂下降后显著增多。结论:CVF激活补体可使外周血白细胞数明显改变并显著增强其功能,提示补体可能参与白细胞功能的调节。
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关 键 词: | 眼镜蛇毒因子 补体 白细胞 |
Effect of complementary activity with cobra venom factor on the number and action of leukocytes in peripheral blood of rats |
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Abstract: | AIM: To observe the effect of complementary activity with cobra venom factor on the number and action of leukocytes in peripheral blood of rats. METHODS: Stephylococcus aureus of phagocytosis test and blood cell counting plate were applied. RESULTS: Cobra venom factor(CVF), 10 mg·kg-1, given to rats, showed prominently enhancing of leukocyte actions: increase in leukocytes bacteriophagic ratio from 207%±49% to 425%±55%; and increase in leukocytes adherence ratio from 734%±83% to 936%±98%. Meanwhile, the number of leukocytes changed. CONCLUSION: Complement might be participated in the mediating of leukocytes action, and complementary activity with CVF could significantly increase the action and number of leukocytes. |
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Keywords: | cobra venom factor complement leukocytes |
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