| 丹参酮、纳络酮对缺血再灌注心肌局部血流量的影响 |
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| 引用本文： | 杨天德,刘桥义.丹参酮、纳络酮对缺血再灌注心肌局部血流量的影响[J].中国药理学通报,1997,13(1):45-47. |
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| 作者姓名： | 杨天德 刘桥义 |
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| 作者单位： | 第三军医大学新桥医院麻醉科 |
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| 摘 要： | 目的：观察丹参酮、纳络酮对缺血再灌注心肌局部血流量的影响。方法：用结扎冠状动脉左前降支的方法复制犬心肌缺血再灌注模型，心肌局部血流量用氢气清除法测定。结果：丹参酮、纳络酮均能明显增加正常及部分再灌注心肌血流量，丹参酮主要增加缺血周围区血流量，纳络酮可增加缺血中心区及周围区血流量。结论：丹参酮、纳络酮均能缩小缺血区范围，纳络酮还能减轻缺血程度。
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| 关 键 词： | 心肌局部血流量 缺血／再灌注 丹参酮 纳络酮 犬 |
Effects of tanshinone and naloxone on regional myocardial blood flow during ischemia and reperfusion in dogs |
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| YANG Tian De,LIU Qiao Yi,TAO Jun,WANG Zhou Qi.Effects of tanshinone and naloxone on regional myocardial blood flow during ischemia and reperfusion in dogs[J].Chinese Pharmacological Bulletin,1997,13(1):45-47. |
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| Authors: | YANG Tian De LIU Qiao Yi TAO Jun WANG Zhou Qi |
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| Abstract: | AIM: To investigate the effects of tanshinone and naloxone on regional myocardial blood flow (RMBF) during ischemia and reperfusion. METHOD: Dog′s ischemia/reperfusion model was carried out by ligation of left anterior coronary descending. Regional myocardial blood flow was measured with hydrogen gas clearance technique. RESULT: Both tanshinone and naloxone increased RMBF significantly in normal and partial reperfused myocardium; Tanshinone mainly increased RMBF in peri ischemic; and naloxone increased RMBF in core and peri ischemic myocardium. CONCLUSION: Tanshinone and naloxone may reduce the size of ischemic myocardium, but naloxone may lighten the degree of ischemia. |
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| Keywords: | regional myocardial blood flow ischemia/reperfusion tanshinone naloxone dog hydrogen gas clearance technique |
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