| 7-氯苄基四氢巴马汀对离体大鼠心肌缺血再灌损伤的保护作用 |
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| 引用本文： | 郑泉,黄文龙.7-氯苄基四氢巴马汀对离体大鼠心肌缺血再灌损伤的保护作用[J].中国药理学通报,1997,13(3):227-229. |
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| 作者姓名： | 郑泉 黄文龙 |
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| 作者单位： | 同济医科大学药理教研室，中国药科大学药物化学研究室 |
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| 摘 要： | 目的：研究７－氯苄基四氢巴马汀对离体大鼠心肌缺血再灌损伤的影响。方法：利用Ｌａｎｇｅｎｄｏｒｆ大鼠心脏，结扎冠状动脉前降支（ＬＡＤ），缺血１０ｍｉｎ后，再灌注２０ｍｉｎ，造成缺血再灌损伤模型。结果：７－氯苄基四氢巴马汀（７－ｃｈｌｏｒＢＴＨＰ）可明显减慢心率，消除再灌注引起的心室纤颤，明显缩短心律失常持续时间，并能抑制离体大鼠心肌缺血、复灌时磷酸肌酸激酶（ＣＰＫ）及乳酸脱氢酶（ＬＤＨ）释放增加。结论：７－ｃｈｌｏｒＢＴＨＰ具有抗离体大鼠再灌注心律失常作用，对缺血再灌注损伤心肌有保护作用，其作用机制可能与其减慢心率，减少缺血复灌时心肌酶释放有关。
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| 关 键 词： | 7-chlor BTHP 心肌 缺血再灌损伤 |
Protective effects of 7 chlor BTHP on ischemia reperfusion in isolated rat hearts |
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| ZHENG Quan,YAO Wei Xing,XIA Guo Jin,JIANG Ming Xing,HUANG Wen Long ,HUANG Chen Ya ,PENG Si Xun.Protective effects of 7 chlor BTHP on ischemia reperfusion in isolated rat hearts[J].Chinese Pharmacological Bulletin,1997,13(3):227-229. |
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| Authors: | ZHENG Quan YAO Wei Xing XIA Guo Jin JIANG Ming Xing HUANG Wen Long HUANG Chen Ya PENG Si Xun |
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| Institution: | ZHENG Quan,YAO Wei Xing,XIA Guo Jin,JIANG Ming Xing,HUANG Wen Long 1,HUANG Chen Ya 1,PENG Si Xun 1 |
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| Abstract: | S AIM: To study the effects 7 chlor BTHP on ischemia reperfusion in isolated rat heart. METHODS: The ischemia reperfusion model was performed with left anterior descending(LAD) occlusion and reperfusion in langendorff rat heart. RESULTS: 7 chlor BTHP (10 μmol·L -1 ) abolished ventricular fibrillation (VF), significantly shorten duration of arrhythmias, slowed down heart rate, obviously decreased the release of myocardial enzyme creatine phispokinase (CPK) and lactate dehydrogenase (LDH). CONCLUSIONS: 7 chlor BTHP could protect myocardium against ischemic reperfused damage and the mechanism of protection was associated with decreasing heart rate of isolated heart and decreasing the release of myocardial enzyme. |
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| Keywords: | chlor BTHP myocardium ischemia reperfusion injury |
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