中枢烟碱受体亚型对小鼠被动回避行为的影响

目的：探讨中枢烟碱受体亚型在学习、记忆中的作用。方法：采用小鼠的被动回避反应法，观察四种不同选择性的烟碱受体（Ｎ受体）拮抗剂对学习和记忆行为的影响。结果：脑室注射ｋａｐｐａ－银环蛇毒（κ－ＢＴＸ）和六烃季铵（Ｃ６）明显抑制小鼠的学习和记忆行为的获得，且κ－银环蛇毒的作用有量—效关系；而α－银环蛇毒（α－ＢＴＸ）和双氢β－刺酮碱（ＤＨＢＥ）对小鼠的被动回避反应无明显影响。结论：中枢烟碱受体亚型在学习、记忆中起不同的作用，对κ－ＢＴＸ敏感的烟碱受体亚型可能在学习记忆中发挥重要作用。

Effects of subtypes of central nicotinic receptors on the passive avoidance responses in mice

Objective: Research of different central subtypes of nicotinic receptors involved in learning and memory. Methods:Four different selective nicotinic antagonists were investigated for their effects on learning and memory behaviour by two passive avoidance responses inmice. Results:When administered intraventricularly, kappa bungarotoxin (κ BTX) and hexamethonium(C 6) inhibited significantly learning and memory acquisition of mouse, and κ BTX produced this effect with a good dose response curve. α bungarotoxin(α BTX) and dihydro β erythroidine(DHBE) did not significantly affected the passive avoidance responses in mice. Conclusion: Different nicotinic antagonists had different effects on learning and memory behaviour, the subtype of central nicotinic receptor sensitive to κ BTX seemed to play an important role in learning and memory.