正常大鼠、高血压大鼠局灶性脑缺血损伤及 764-3 的保护作用

目的：观察丹参有效成分７６４－３对正常大鼠和高血压大鼠脑缺血损伤的保护作用。方法：分别阻断正常大鼠和肾性高血压大鼠一侧大脑中动脉，观察缺血２４ｈ其脑比重、脑血管通透性、脂质过氧化代谢产物——丙二醛等脑损伤指标的改变，以及丹参有效成分７６４－３对这种改变的作用。结果：正常大鼠脑局灶性缺血２４ｈ后，皮层、尾核、海马的比重降低，形成了脑水肿，脑血管通透性、脑丙二醛的含量也明显增加，丹参有效成分７６４－３对这种改变有明显抑制作用。高血压大鼠仅杏仁核形成水肿，其脑血管通透性、脑丙二醛的含量明显增加，７６４－３对脑丙二醛增加和脑水肿的形成有明显抑制作用，对血管通透性的增加无抑制作用。结论：丹参有效成分７６４－３对脑缺血具有保护作用。

Development of brain edema in hypertensive and normotensive rats 24 hours after focal cerebral ischemia and effect of 764 3 on it

Objective: To observe the effect of 764 3 on the injury of cerebral ischemia in normotensive and reno hypertensive rats. Methods: The specific gravity of brain, content of MDA in brain and cerebral vascular permeability to Evans blue were investigated in normotensive and reno hypertensive rats 24 hours after focal cerebral ischemia. Results: The cortex,caudate and hippocampus developed edema in normotensive rats and amygdala developed edema in hypertensive rats. The content of MDA and cerebral vascular pemeability increased not only in normotensive rats but in hypertensive rats. 764 3 administation could ameliorate these abnormalities except the increased cerebral vascular permeability in hypertensive rats. Conclusion: It was showed that 764 3 had some protect effect on cerebral ischemia injury in normotensive and reno hypertensive rats.