TOLL样受体的研究进展及其与自身免疫性疾病的关系

TOLL样受体（toll-like receptors,TLRs）在连接天然免疫和获得性免疫中起重要作用,它们通过多种信号转导识别外来微生物,越来越多的研究表明TLRs会促成多种自身免疫病（系统性红斑狼疮、类风湿关节炎等）的发生,而且在疾病的发病机理中起作用,相信随着研究的深入将会揭开自身免疫病发病机理,从而指导临床治疗.

Research advancements of toll-like receptors and their relationships with autoimmune disorders

Toll-like receptors （TLRs） play a pivotal role in innate and adaptive immune responses. They recognise pathogens through signaling pathways. Accumulating evidence suggests TLRs are important in autoimmune disorders （SLE, RA）. A greater understanding of the processes by which TLRs regulate adaptive immunity may yield new approaches to the treatment and prevention of autoimmune disorders.