喷他佐辛超前镇痛在腹腔镜胆囊切除术中的应用

目的观察喷他佐辛对腹腔镜胆切除术（Lc）是否具有超前镇痛作用。方法将60例择期LC患者（ASA分级Ⅰ～Ⅱ级）随机分为研究组和对照组。观察24h内恶心、呕吐、瘙痒等不良应的发生率。研究组在全麻诱导前静脉缓慢推注喷他佐辛0．5mg／kg。对照组给予生理盐水推注。记录自主呼吸恢复时间、睁眼时间、拔管时间及术后1、2．4、8、12、24h的疼痛程度并进行评价。结果两组呼吸恢复时间、睁眼时间、拔管时间差异无统计学意义（P〉0．05）；研究组疼痛程度明显低于对照组（P〈0．05）；术后患者的并发症的发生情况差异无统计学意义（P〉0．05）。结论术前应用喷他佐辛0．5mg／kg能有效减轻腹腔镜胆囊切除术的术后疼痛，起到超前镇痛作用，是一种理想的长效中枢性镇痛方法。

The application of pentazocine preemptive analgesia in laparoscopic cholecystectomy

Objective To observe the role of preemptive analgesia of pentazocine in laparoscopic cholecystectomy （LC）. Methods Sixty patients with elective LC （ ASA grade Ⅰ to grade Ⅱ） were randomly divided into pre-emptive analgesia group and the control group. Within 24 h, the incidence of nausea, vomiting, itching, etc. were observed. Pre-emptive analgesia group （A group） received intravenous slow bolus injection of pentazocine 0. 5 mg/kg, induction of general anesthesia. The control group （ B group） were injected with saline. The spontaneous breathing recovery time, eyes open time and extubation time and pain assessment at 1, 2, 4, 8, 12, 24 h of treat- ment were recorded. Results The difference in breathing recovery time, eyes open time and extubation time between two groups was not statistically significant（ P 〉 0. 05 ）. The pain intensity in A group was significantly lower than that in group（ P 〈 0. 05 ）. The occurrence of postoperative complications between two groups was no significant difference （P 〉 0. 05）. Conclusion Preoperative application of pentazocine 0. 5 mg/kg can effectively reduce the postoperative laparoscopic cholecystectomy pain, with a role of preemptive analgesia,is an ideal long-term central analgesia.