早发型子痫前期的临床特征及其预后分析

目的 探讨早发型子痫前期的临床特点及围产儿结局.方法 回顾性分析2004-01～2009-12间524例子痫前期病例的有关临床资料,根据孕周将其分为早发组（〈32周）,晚发组（≥32周）,比较两组病例发病情况、病情特点及母婴并发症等.结果 与晚发组子痫前期相比,早发型子痫前期具有明显的高血压家族史（P〈0.01）;易发展成重度子痫前期（P〈0.01）,出现肝、肾功能损害（P〈0.01）;围产儿病死率高（P〈0.01）.分娩孕期与围产儿预后显著相关（P〈0.05）.结论 早发型子痫前期对孕妇的危害主要是围产儿不良结局发生率增高.

Clinical features and prognostic analysis of early-onset preeclampsia

Objective To evaluate the clinical features and perinatal outcome of early-onset preeclampsia （PE）. Methods A retrospective analysis of 524 cases of preeclampsia from January 2004 to December 2009 was performed. All the patients were divided into two groups according to gestational week： early-onset preeclampsia group（ 〈 32 weeks）and lately-onset preeclampsia group （≥ 32 weeks）. The data were analyzed on the incidence, manifestation, maternal and fetal complications. Results Compared with the lately-onset preeelampsia group, the early-onset preeelampsia group had significant family history of hypertension and preeclampsia（ P 〈 0.01 ） ; easily developed into severe preeclampsia and renal dysfunction and hepatic dysfunction（ P 〈 0. 01 ） ; had high perinatal mortality （P 〈 0.01 ） ; The gestational time at delivery was significantly correlated with perinatal prognosis （ P 〈 0. 05 ）. Conclusion Early-onset preeclampsia is a severe type of preeclampsia, which has high perinatal mortality.