| 严重体表烧伤早期大鼠肾脏内皮素－1的基因表达 |
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| 引用本文： | 王旭,吴雄飞,高建川,杨宗城,黎鳌.严重体表烧伤早期大鼠肾脏内皮素－1的基因表达[J].第三军医大学学报,1996(5). |
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| 作者姓名： | 王旭 吴雄飞 高建川 杨宗城 黎鳌 |
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| 作者单位： | 第三军医大学附属西南医院烧伤研究所 |
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| 摘 要： | 应用分子斑点杂交、原位杂交技术，观察了大鼠烧伤早期肾脏各时相点的内皮素－１（ＥＴ－１）ｍＲＮＡ的表达和定位变化。结果表明：烧伤早期肾脏ＥＴ－１ｍＲＮＡ含量明显上升，分布有所变化，且为肾脏自身分泌释放（自分泌／旁分泌）。文中还简要讨论了上述变化的原因
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| 关 键 词： | 灼伤 肾脏 内皮素 原位杂交 |
Expressionofendothelin 1geneinearlystageaftersevereburnsinrats |
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| Wang Xu,Wu Xiongfei,Gao Jianchuan,Yang Zongcheng,Li Ao.Expressionofendothelin 1geneinearlystageaftersevereburnsinrats[J].Acta Academiae Medicinae Militaris Tertiae,1996(5). |
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| Authors: | Wang Xu Wu Xiongfei Gao Jianchuan Yang Zongcheng Li Ao |
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| Abstract: | The expression and localization changes of endothelin 1 mRNA (ET 1 mRNA) at different time points after severe burns were observed in the kidneys of rats with northern blot and in situ hybridization. It was found that ET 1 mRNA content was significantly increased and its localization was changed. ET 1 was mainly secreted and released by the kidneys themselves (auto or para secretion). The reasons for the above findings were briefly discussed. |
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| Keywords: | burns kidney endothelin in situ hybridization rat |
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