非水酸碱电位滴定法测定阿德福韦酯原料药含量

目的：建立测定阿德福韦酯原料药含量的非水酸碱电位滴定方法。方法：以无水冰醋酸．醋酐(1：3)作为溶剂，以高氯酸标准溶液(0．1mol／L)为滴定剂进行非水电位滴定。结果：阿德福韦酯原料药平均含量为99．7％，RSD为0．2％。结论：本方法准确，重现性好，适用于阿德福韦酯原料药的质量控制。

Determination of the adefovir dipivoxil raw material by nonaqueous acid-base e-lectrolytic titrations

Objective: To establish nonaqueous acicle - base electrolytic titrations method for the determination of adefovir dipivoxil raw material, and investigate the infulents of the proportion of acetic anhydride in the acetric anhydride and anhydro-glacial acetic acid mixed solution. Methods:75% acetric anhydride was selected as the solvent, and 0. 1 mol/L perchloric was selected as the standard solution to determine the content of adefovir dipivoxil in raw material. Results:It was found that the end point was changed more acuate with the increasing of acetric anhydride proportion in solvent. The average recovery of adefovir dipivoxil raw material was 99. 7% and RSD was 0. 2% . Conclusion:The method was simple, accurate, and is suitable for the quality control of adefovir dipivoxil raw material.