Correlation between cathepsin D serum concentration and carotid intima-media thickness in hemodialysis patients |
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| Authors: | Seyed Adel Moallem Fatemeh Nazemian Sepideh Eliasi Seyed Ali Alamdaran Jamal Shamsara Amir Hooshang Mohammadpour |
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| Affiliation: | (1) Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;(2) Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran;(3) Nephrology Ward, Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran;(4) Radiology Department, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran;(5) Pharmaceutical Research Center, Mashhad University of Medical Sciences, P.O. Box 91775-1365, Mashhad, Iran; |
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| Abstract: | Aim Cardiovascular (CV) disease is the leading cause of death in hemodialysis (HD) patients, and approximately half of mortalities in HD patients are attributed to CV disease. Atherosclerosis is the most frequent cause of CV complications in patients with end-stage renal disease (ESRD). Based on recent studies, cathepsin D has been suggested as a potential marker of atherosclerosis, and we hypothesized that there is an association between serum concentration of cathepsin D and carotid intima-media thickness (CIMT) in hemodialysis patients. |
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