Evaluation of the activity of receptor-operated Ca2+ channels in rat portal vein in induced hyperthyroidism |
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| Authors: | Reddy A G Mishra S K Prakash V R Tandan S K Tripathi H C Varshney V P |
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| Affiliation: | Division of Phramacology & Toxicology, Indian Veterinary Research Institute, Izatnagar. |
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| Abstract: | The activity of receptor-operated Ca2+ channels (ROCCs) was studied in rat portal vein in L-thyroxine-induced experimental hyperthyroidism. The following parameters were evaluated: 1. NE-stimulated 45Ca influx. 2. CaCl2-induced contractile responses in Ca2+ free NE-stimulated tissues to calculate EC50 value of CaCl2. The NE (10(-6)mol) stimulated 45Ca influx and the mean EC50 value of CaCl2 did not differ significantly in portal veins isolated from hyperthyroid rats as compared to those of euthyroid control rats. The study revealed no significant change in the functional status of ROCCs in experimental hyperthyroidism. |
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