| 聚乙二醇衍生物及其蛋白药物修饰研究进展 |
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| 引用本文： | 张羽,连治国,徐明波,冯芳.聚乙二醇衍生物及其蛋白药物修饰研究进展[J].药学实践杂志,2018,36(4):301-306,328. |
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| 作者姓名： | 张羽 连治国 徐明波 冯芳 |
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| 作者单位： | 中国药科大学, 江苏 南京 210009;北京双鹭药业股份有限公司, 北京 100041,北京双鹭药业股份有限公司, 北京 100041,北京双鹭药业股份有限公司, 北京 100041,中国药科大学, 江苏 南京 210009 |
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| 摘 要： | 聚乙二醇及其衍生物因其出色的亲水性、生物相容性、生物学惰性等特性而被广泛应用于蛋白药物修饰，其修饰可有效降低蛋白药物的免疫原性并延长体内半衰期。聚乙二醇衍生物的发展经历了第一代随机修饰，第二代特异性和功能性修饰，以及第三代分支型结构的应用。其应用也从简单的药物修饰扩展到生物传感、药物传输等方面。
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| 关 键 词： | 聚乙二醇衍生物 聚乙二醇修饰 蛋白药物 长效 |
| 收稿时间： | 2017/11/23 0:00:00 |
| 修稿时间： | 2018/3/30 0:00:00 |
Advances in the development of PEG derivatives and pegylated protein drugs |
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| ZHANG Yu,LIAN Zhiguo,XU Mingbo and FENG Fang.Advances in the development of PEG derivatives and pegylated protein drugs[J].The Journal of Pharmaceutical Practice,2018,36(4):301-306,328. |
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| Authors: | ZHANG Yu LIAN Zhiguo XU Mingbo and FENG Fang |
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| Institution: | China Pharmaceutical University, Nanjing 210009, China;Beijing SL Pharmaceutical Co., Ltd., Beijing 100041, China,Beijing SL Pharmaceutical Co., Ltd., Beijing 100041, China,Beijing SL Pharmaceutical Co., Ltd., Beijing 100041, China and China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Polyethylene glycol and its derivatives are widely used in protein drug modification due to the excellent hydrophilicity, biocompatibility and bioinertia. The pegylation makes it possible that protein has lower immunogenicity and longer half-life. PEG derivatives had undergone three generations, from random modifications, to site-specific and functional modifications, and then branched structures. The application of PEG derivatives also extends to biosensing and drug delivery. Advances in the development of PEG derivatives and pegylated protein drugs were reviewed in this paper. |
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| Keywords: | PEG derivatives pegylation protein drugs long-acting |
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