89SrCl2治疗恶性肿瘤骨转移的影响因素分析

目的 探讨⁸⁹SrCl₂治疗恶性肿瘤骨转移的疗效影响因素。方法 选择南充市川北医学院附属医院2013年2月至2016年9月行⁸⁹SrCl₂治疗的恶性肿瘤骨转移患者99例，分析患者的年龄、性别、肿瘤病理类型、⁸⁹SrCl₂治疗次数、手术切除原发灶、放疗、化疗、肿瘤骨转移的病灶数量、联合止痛药状况以及碱性磷酸酶（ALP）是否会影响⁸⁹SrCl₂的治疗效果。结果 ⁸⁹SrCl₂治疗的总有效率为63.6%。单因素分析结果显示不同肿瘤病理类型、不同治疗次数、是否联合放射治疗、是否手术切除原发灶、不同肿瘤骨转移病灶数量及是否联合止痛药患者的治疗效果进行比较，差异具有统计学意义（P<0.05）。logistics回归分析显示，患者的肿瘤病理类型、⁸⁹SrCl₂治疗次数、手术切除原发灶、肿瘤骨转移的病灶数量及联合止痛药是影响⁸⁹SrCl₂疗效的独立因素（P<0.05）。结论 肿瘤病理类型、⁸⁹SrCl₂治疗次数、手术切除原发灶、肿瘤骨转移病灶数量以及联合止痛药能影响⁸⁹SrCl₂治疗恶性肿瘤骨转移的疗效。

Analysis of influencing factors of strontium-89 in treatment of bone metastases of malignant tumors

Objective To investigate the influencing factors of the treatment of bone metastases of malignant tumors with strontium chloride (⁸⁹SrCl₂).Methods Ninety-nine patients of bone metastases were collected from Nanchong Affiliated Hospital of North Sichuan Medical College from Feb 2013 to Sept 2016, and grouped according to their treatment result. Whether the age, sex, pathological type of tumor, the treatment times of ⁸⁹SrCl₂, operation, radiotherapy, chemotherapy, number of bone metastases, analgesics and the level of alkaline phosphatase (ALP) had influence on the treatment result of ⁸⁹SrCl₂ was analyzed.Results The total efficiency of ⁸⁹SrCl₂ treatment was 63.6%. The univariate analysis showed that different tumor pathological types, different times of treatment, whether combined with radiotherapy, surgical resection or not, the number of different tumor bone metastases, and whether combined with analgesics were statistically significant (P< 0.05). These factors were brought into multivariate Logistics regression analysis to show that the pathological type of the tumor, the times of ⁸⁹SrCl₂ treatment, operation, the number of tumor bone metastases, and whether combined with analgesic are the independent factors affecting the efficacy of ⁸⁹SrCl₂.Conclusion The pathological type of tumor, the times of patients treated with ⁸⁹SrCl₂, operation, the number of tumor bone metastases and whether combined with analgesic affect the efficacy of ⁸⁹SrCl₂.