颈腰康胶囊联合双氯芬酸钠治疗腰椎间盘突出症的临床研究

目的观察颈腰康胶囊联合双氯芬酸钠治疗腰椎间盘突出症的临床疗效。方法选取2018年1月—2018年12月在宜宾市第一人民医院就诊的腰椎间盘突出症患者86例,随机分为对照组和治疗组,每组各43例。对照组口服双氯芬酸钠缓释片,0.1g/次,1次/d;治疗组在对照组治疗基础上口服颈腰康胶囊,3粒/次,3次/d。两组患者均治疗4周。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状改善情况以及白细胞介素-1(IL-1)和IL-6水平。结果治疗后,对照组和治疗组临床有效率分别为79.07%和90.70%,两组比较差异有统计学意义(P0.05)。治疗后,两组患者目测类比疼痛评分(VAS)和Oswestry功能障碍指数(ODI)评分均明显降低(P0.05),且治疗组患者VAS和ODI评分明显低于对照组(P0.05)。治疗后,两组患者IL-1和IL-6水平均明显下降(P0.05),且治疗组患者IL-1和IL-6水平明显低于对照组(P0.05)。结论颈腰康胶囊联合双氯芬酸钠治疗腰椎间盘突出症治疗效果显著,能有效改善患者临床症状和炎症反应。

Clinical study on Jingyaokang Capsules combined with diclofenac sodium in treatment of lumbar disc herniation

Objective To observe the clinical effect of Jingyaokang Capsules combined with diclofenac sodium in treatment of lumbar disc herniation. Methods Patients (86 cases) with lumbar disc herniation in Yibin First People''s Hospital from January 2018 to December 2018 were randomly divided into control and treatment groups, and each group had 43 cases. Patients in the control group were po administered with Dicolfenac Sodium Sustained Release Tablets, 0.1 g/time, once daily. Patients in the treatment group were po administered with Jingyaokang Capsules on the basis of the control group, 3 grains/time, three times daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the improvement of clinical symptoms, IL-1 and IL-6 levels in two groups before and after treatment were compared. Results After treatment, the clinical efficacy and in the control and treatment groups was 79.07%, and 90.70% respectively, and there were differences between two groups (P<0.05). After treatment, the VAS and ODI scores in two groups were significantly decreased (P<0.05), and these scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, IL-1 and IL-6 levels in two groups were significantly decreased (P<0.05), and these serological indexes in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Jingyaokang Capsules combined with diclofenac sodium has significant effect in treatment of lumbar disc herniation can effectively improve the clinical symptoms and inflammatory response.