| 双硫仑抗肿瘤活性及在放射生物学中的研究进展 |
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| 引用本文： | 罗辉,乔丽丽,李永翰,张丹丹,贾雪超,聂文娜,郑晓丽,孙亚楠,范诚诚,葛红.双硫仑抗肿瘤活性及在放射生物学中的研究进展[J].中华放射医学与防护杂志,2018,38(8):631-634. |
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| 作者姓名： | 罗辉 乔丽丽 李永翰 张丹丹 贾雪超 聂文娜 郑晓丽 孙亚楠 范诚诚 葛红 |
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| 作者单位： | 450014 郑州大学第二临床学院研究生部,100021 北京, 中国医学科学院 北京协和医学院肿瘤医院/肿瘤研究所,450003 郑州, 中美荷美尔肿瘤研究院,450003 郑州, 中美荷美尔肿瘤研究院,450003 郑州, 中美荷美尔肿瘤研究院,450003 郑州, 中美荷美尔肿瘤研究院,450008 郑州大学附属肿瘤医院放疗科,450008 郑州大学附属肿瘤医院放疗科,450008 郑州大学附属肿瘤医院放疗科,450008 郑州大学附属肿瘤医院放疗科 |
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| 基金项目： | 国家自然科学基金（81372436） |
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| 摘 要： | 双硫仑（disulfiram，DSF）为临床广泛应用的抗酗酒药物。然而，近年来的一些研究表明，DSF具有极强的抗肿瘤活性，已有临床试验报道其可提高肿瘤患者生存率；并对其抗肿瘤的分子机制进行了深入的阐述。另外，放射生物学研究发现DSF可以减轻射线对机体正常细胞的损伤，并通过其与铜离子形成复合物、抑制肿瘤干细胞、抑制泛素-蛋白酶体活性等机制增强肿瘤细胞的放疗敏感性，极有希望作为放化疗的辅助用药，提高放化疗疗效。本文详细论述了双硫仑抗肿瘤临床研究现状、分子机制，在肿瘤放射生物学中的研究及其应用前景。
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| 关 键 词： | 双硫仑 肿瘤 临床研究 分子机制 放射敏感性 |
| 收稿时间： | 2018/1/12 0:00:00 |
Research progresses of the roles of disulfiram in anticancer activity and radiobiology |
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| Luo Hui,Qiao Lili,Li Yonghan,Zhang Dandan,Jia Xuechao,Nie Wenn,Zheng Xiaoli,Sun Yanan,Fan Chengcheng and Ge Hong.Research progresses of the roles of disulfiram in anticancer activity and radiobiology[J].Chinese Journal of Radiological Medicine and Protection,2018,38(8):631-634. |
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| Authors: | Luo Hui Qiao Lili Li Yonghan Zhang Dandan Jia Xuechao Nie Wenn Zheng Xiaoli Sun Yanan Fan Chengcheng and Ge Hong |
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| Institution: | Division of Graduate, The Second Clinical Medical School and the Second Affiliated Hospital of Zhengzhou University, Zhengzhou 450014, China,Department of Etiology and Carcinogenesis, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China,China-US Hormel Cancer Institute, Zhengzhou 450003, China,China-US Hormel Cancer Institute, Zhengzhou 450003, China,China-US Hormel Cancer Institute, Zhengzhou 450003, China,China-US Hormel Cancer Institute, Zhengzhou 450003, China,Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China,Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China,Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China and Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China |
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| Abstract: | Disulfiram (DSF) has been widely used in clinical treatment of alcoholism. To date, in vivo and in vitro experiments have demonstrated that DSF has strong anti-cancer activity and could improve patient''s survival, and the underlying mechanism has been elaborated. In addition, it was reported that, during radiotherapy, DSF could protect normal tissue and cells meanwhile enhance the radiosensitivity of tumor cells by forming complexes with copper ions, suppressing cancer stem cells and inhibiting ubiquitin-proteasome system activity in cancer cells. This review summarizes the completed and ongoing clinical trials of disulfiram, and its anti-tumor mechanisms and advances in radiation biology. |
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| Keywords: | Disulfiram Cancer Clinical studies Molecular mechanism Radiosensitivity |
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