| 缬沙坦纳米骨架系统在大鼠体内的药动学研究 |
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| 引用本文： | 刘婧琳,吴春暖,王冠元,代文兵,张洁.缬沙坦纳米骨架系统在大鼠体内的药动学研究[J].现代药物与临床,2019,34(12):3524-3528. |
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| 作者姓名： | 刘婧琳 吴春暖 王冠元 代文兵 张洁 |
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| 作者单位： | 天津医科大学肿瘤医院 国家肿瘤临床医学研究中心 天津市"肿瘤防治"重点实验室 天津市恶性肿瘤临床医学研究中心 药学部,天津,300060;北京大学 药学院,北京,100191 |
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| 基金项目： | 国家重大科学研究计划项目（2015CB932100） |
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| 摘 要： | 目的采用HPLC法研究缬沙坦纳米骨架系统在SD大鼠体内的生物利用度。方法采用BDS Hypercil C_(18)柱(250mm×4.6 mm,5μm);流动相:甲醇–乙腈–0.01 mol/L磷酸二氢钾(44∶24∶32);体积流量1.0 mL/min;检测波长250 nm;柱温30℃;进样量20μL。取雄性SD大鼠12只,随机分为2组,按照缬沙坦20 mg/kg分别ig缬沙坦胶囊和缬沙坦纳米骨架系统,绘制血药浓度–时间曲线,采用DAS 2.1.1软件计算主要动力学参数C_(max)、t_(max)、AUC、F。结果缬沙坦在0.481～48.1μg/mL线性关系良好。定量限为0.4μg/mL,准确度、灵敏度、精密度和专属性均符合体内分析方法学要求。缬沙坦纳米骨架系统药时曲线下面积比缬沙坦胶囊提高154.78%,显著提高缬沙坦的体内生物利用度。结论缬沙坦纳米骨架系统血药浓度变化相对较为平缓,有望成为难溶性药物的新型给药方式。
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| 关 键 词： | 缬沙坦纳米骨架系统 缬沙坦胶囊 缬沙坦 生物利用度 高效液相色谱 |
| 收稿时间： | 2019/9/18 0:00:00 |
Pharmacokinetics of valsartan nanomatrix drug delivery system in rats in vivo |
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| LIU Jing-lin,WU Chun-nuan,WANG Guan-yuan,DAI Wen-bing and ZHANG Jie.Pharmacokinetics of valsartan nanomatrix drug delivery system in rats in vivo[J].Drugs & Clinic,2019,34(12):3524-3528. |
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| Authors: | LIU Jing-lin WU Chun-nuan WANG Guan-yuan DAI Wen-bing and ZHANG Jie |
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| Institution: | Department of Pharmacy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin''s Clinical Research Center for Cancer, Tianjin 300060, China,Department of Pharmacy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin''s Clinical Research Center for Cancer, Tianjin 300060, China,Department of Pharmacy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin''s Clinical Research Center for Cancer, Tianjin 300060, China,Peking University School of Pharmaceutical Sciences, Beijing 100191, China and Department of Pharmacy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin''s Clinical Research Center for Cancer, Tianjin 300060, China |
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| Abstract: | |
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| Keywords: | valsartan nanomatrix drug delivery system valsartan capsules valsartan bioavailability HPLC |
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