| 桉属间苯三酚-萜烯类化合物及其抗肿瘤作用机制研究进展 |
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| 引用本文： | 华丹,王维亭,周雪霞,王虔,孙翠云,石翠娟,汤立达,于士柱. 桉属间苯三酚-萜烯类化合物及其抗肿瘤作用机制研究进展[J]. 中草药, 2019, 50(24): 6156-6161 |
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| 作者姓名： | 华丹 王维亭 周雪霞 王虔 孙翠云 石翠娟 汤立达 于士柱 |
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| 作者单位： | 天津医科大学总医院, 天津 300052,天津药物研究院, 天津 300193,天津医科大学总医院, 天津 300052,天津医科大学总医院, 天津 300052,天津医科大学总医院, 天津 300052,天津医科大学总医院, 天津 300052,天津药物研究院, 天津 300193,天津医科大学总医院, 天津 300052 |
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| 基金项目： | 国家自然科学基金项目（81302002）；国家自然科学基金项目（81402050）；国家自然科学基金项目（81502166）；国家自然科学基金项目（81672592）；国家自然科学基金项目（81872061）；天津市自然科学基金项目（14JCQNJC12300）；天津市自然科学基金项目（15JCZDJC34600）；天津市自然科学基金项目（15JCYBJC49900）；天津市自然科学基金项目（16JCQNJC13400）；天津市自然科学基金项目（17JCYBJC27100）；中国留学基金委项目（201606945004） |
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| 摘 要： | 间苯三酚-萜烯为桉属Eucalyptus L.Herit植物中天然存在的主要活性成分，具有独特的聚酮-二萜骨架，抗癌活性显著，是抗癌先导化合物的潜在来源。综述桉属植物抗癌活性天然间苯三酚-萜烯类化合物的结构、作用机制，为间苯三酚-萜烯类抗癌新药的研发提供参考。
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| 关 键 词： | 桉属 间苯三酚-萜烯 抗肿瘤 作用机制 聚酮-二萜骨架 |
| 收稿时间： | 2019-07-19 |
Research progress on phloroglucinol terpenes from Eucalyptus genus and their antitumor mechanism |
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| HUA Dan,WANG Wei-ting,ZHOU Xue-xi,WANG Qian,SUN Cui-yun,SHI Cui-juan,TANG Li-da and YU Shi-zhu. Research progress on phloroglucinol terpenes from Eucalyptus genus and their antitumor mechanism[J]. Chinese Traditional and Herbal Drugs, 2019, 50(24): 6156-6161 |
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| Authors: | HUA Dan WANG Wei-ting ZHOU Xue-xi WANG Qian SUN Cui-yun SHI Cui-juan TANG Li-da YU Shi-zhu |
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| Affiliation: | General Hospital of Tianjin Medical University, Tianjin 300052, China,Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China,General Hospital of Tianjin Medical University, Tianjin 300052, China,General Hospital of Tianjin Medical University, Tianjin 300052, China,General Hospital of Tianjin Medical University, Tianjin 300052, China,General Hospital of Tianjin Medical University, Tianjin 300052, China,Tianjin Institute of Pharmaceutical Research, Tianjin 300193, China and General Hospital of Tianjin Medical University, Tianjin 300052, China |
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| Abstract: | Phloroglucinol terpenes are the mainly naturally active ingredients from Eucalyptus genus. Based on the modern pharmacological studies, phloroglucinol terpenes with unique polyketoditerpenoid skeleton have been confirmed to have the anticancer activity, which could be the important source to find the novel potential anticancer lead compounds. In this article, the structure, antitumor mechanism and activity of these known phloroglucinol terpenes from Eucalyptus genus were reviewed, which can provide the references for the following researches on the novel anticancer drugs of phloroglucinol terpenes. |
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| Keywords: | Eucalyptus L. Herit phloroglucinol terpenes antitumor mechanism polyketoditerpenoid skeleton |
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