基于文献多元分析的类风湿关节炎用药规律研究

目的：基于现代文献探讨中医药治疗类风湿关节炎用药规律。方法：检索中国期刊全文数据库 （CNKI）、万方数据知识服务平台、维普中文科技期刊数据库中关于类风湿关节炎的临床病案与基础研究资 料。检索时限为2000年1月至2016年12月，纳入其中中医药治疗类风湿关节炎的文献，对其中的中药组成、功 效归类、性味归经等参照相关标准进行数据规范化处理。结果：研究最终纳入文献292篇，涉及中药214种，药 物总频次共有5 071次，应用频数分析、聚类分析等方法进行统计分析。频数分析显示类风湿关节炎用药以补 虚药、祛风湿药、活血化瘀药为主，以清热药、解表药、利水渗湿药等药为辅，药味以甘、辛、苦为主，药性则以温 性和平性为主；药物多归经肝经、脾经、肾经。结论：聚类分析结果归纳出黄芪、甘草、当归、乌头、桂枝、薏苡仁、 防风、秦艽、羌活、鸡血藤、川芎、牛膝、威灵仙是治疗类风湿关节炎的核心药物群，关联分析归纳出类风湿关节 炎用药的常用药物组合，发现类风湿关节炎用药特点以补虚扶正、补益肝肾、祛风除湿、活血化瘀通络为主。

Studies on Medication Laws towards Rheumatoid Arthritis Based on Analysis and Comparison of Medicine Literatures

This paper was aimed to study medication laws of traditional Chinese medicine (TCM) towards rheumatoid arthritis (RA) based on modern medicine literatures. The China National Knowledge Infrastructure (CNKI), Wanfang Data knowledge service platform and VIP Database for Chinese Technical Periodicals were searched from January 2000 to December 2016 for relevant literatures on TCM for treatment of RA. The results showed that the database was established and the data were analyzed with statistics method including frequency analysis and cluster analysis. Finally, a total of 292 articles, 214 kinds of herbs were included, with a total frequency of 5071 for herbs. The results of frequency analysis,showed that tonic drugs, medicine for eliminating wind and dampness, drug for invigorating blood circulation and eliminating stasis were the main medications, followed by heat-cleaning drug, relieving external syndrome drug, and dampness-draining drug. The most common tastes of high frequency were sweet, pungent and bitter. The most common natures were warm and mild. The related meridians included the liver meridian, spleen meridian and kidney meridian. It was concluded that the cluster analysis showed medicines in the core group were as following: Astragalus, Licorice, Chinese angelica, Monkshood, Cassia twig, Coix seed, Radix saposhnikoviae, Radix gentianae macrophyllae, Notopterygium, Caulis spatholobi, Rhizoma ligustici wallichii, Twotooth achyranthes root, and Radix clematidis. The common combinations of RA drugs were summarized by association analysis. The medication law of RA treatment is to enrich consumptive disease and support healthy energy, to tonify the liver and kidney, to dispel wind and eliminate dampness, to remove blood stasis and dredge collaterals.