410例患者结直肠腺瘤与幽门螺杆菌感染特征及相关性分析

目的　探讨结直肠腺瘤与幽门螺杆菌感染的关系。 方法　连续性收集在上海交通大学医学院附属仁济医院内镜中心同时行胃镜及结加肠镜的患者共410例患者的病例资料（其中结直肠腺瘤者74人，正常对照组336人）。比较结直肠腺瘤组和健康对照组幽门螺杆菌感染情况的差异。并将结直肠腺瘤组分别按腺瘤的数目、最大径、病理分型分亚组，比较各亚组与幽门螺杆菌感染情况。统计学分析采用t检验与卡方检验，P < 0.05 被认为具有统计学差异。 结果　结直肠腺瘤组和健康对照组幽门螺杆菌感染阳性率分别为29.73%和19.34%，前者高于后者，差异均有统计学意义（P＜0.05）。按腺瘤数目、最大径、病理分型分亚组，各亚组组内幽门螺杆菌感染阳性率差异均无统计学意义（P均＞0.05），但按递进分层与对照组相比均有统计学差异（P均小于0.05）。 结论　结直肠腺瘤可能与幽门螺杆菌感染有直接相关，同时幽门螺杆菌对腺瘤的发展可能有促进作用。

Characteristics and correlation of colorectal adenoma and Helicobacter pylori infection in 410 Patients

AIM: To explore the correlation between Helicobacter pylori(H. pylori) infection and colorectal adenoma. METHODS: We continuously collected a total of 410 patients (74 of colorectal adenoma patients and 336 of normal control patients) in the endoscopy center of Renji Hospital Affiliated to Shanghai Jiao Tong University, all patients went through gastroscopy and colonoscopy within the same day. The difference of H. pylori infection rate between colorectal adenoma group and control group was compared. Then the colorectal adenoma group was divided into subgroups according to the number, maximum diameter and pathological type of adenomas. H. pylori infection rate of each subgroup was compared. Statistical analysis of t test and chi square test were used, and P<0.05 was considered statistically significant. RESULT: The infection rate of H. pylori in colorectal adenoma group and control group were 29.73% and 19.34% respectively, and the difference was statistically significant (P<0.05). H. pylori infection rate within each subgroup showed no significant difference (P>0.05), but stratified analysis according to the progressive layers compared with the control group were statistically significant (P<0.05). CONCLUSION: H. pylori infection is a risk factor and maybe a promote factor for colorectal adenoma.