| MiR-193b在肝癌组织中的表达及临床意义 |
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| 引用本文： | 尹文君,王秋平,刘双全,姜孝新.MiR-193b在肝癌组织中的表达及临床意义[J].南华大学学报(医学版),2018(6):621-624. |
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| 作者姓名： | 尹文君 王秋平 刘双全 姜孝新 |
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| 作者单位： | 南华大学第一附属医院检验科,湖南 衡阳 421001,南华大学第一附属医院检验科,湖南 衡阳 421001,南华大学第一附属医院检验科,湖南 衡阳 421001,南华大学第一附属医院检验科,湖南 衡阳 421001 |
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| 摘 要： | 观察microRNA-193b(miR-193b)在肝癌组织中的表达,并探讨其临床意义。采用荧光实时定量PCR(qRT-PCR)检测40例肝癌组织及相应的癌旁非肿瘤组织标本中miR-193b表达,分析miR-193b表达与患者年龄、性别、肿瘤大小、分化程度、TNM分期及淋巴结转移等临床病理参数的关系,并比较miR-193b高、低表达患者5年生存率。结果显示,相对于癌旁非肿瘤组织,肝癌组织中miR-193b 表达水平明显降低(P<0.01),miR-193b表达与肿瘤分化程度、TNM分期和淋巴结转移相关(P<0.05),与年龄、性别、肿瘤大小无相关性(P>0.05)；与miR-193b低表达组患者相比,高表达组患者5年生存率明显增加(P<0.05)。MiR-193b在肝癌组织呈低表达,可作为评估肿瘤恶性程度及判断预后的分子标记物。
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| 关 键 词： | miR-193b 肝癌 qRT-PCR 病理特征 生存率 |
| 收稿时间： | 2018/3/9 0:00:00 |
| 修稿时间： | 2018/8/14 0:00:00 |
Expression of miR-193b in hepatic cancer tissue and its clinical significance |
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| YIN Wenjun,WANG Qiuping,LIU Shuangquan and JIANG Xiaoxin.Expression of miR-193b in hepatic cancer tissue and its clinical significance[J].Journal of Nanhua University(Medical Edition),2018(6):621-624. |
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| Authors: | YIN Wenjun WANG Qiuping LIU Shuangquan and JIANG Xiaoxin |
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| Institution: | Department of Clinical Laboratory, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China,Department of Clinical Laboratory, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China,Department of Clinical Laboratory, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China and Department of Clinical Laboratory, the First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, China |
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| Abstract: | To observe the expression of microRNA-193b (miR-193b) in hepatic cancer tissue and explore its clinical significance. Quantitative real-time PCR (qRT-PCR) was used to detect the expression of miR-193b in 40 hepatic cancer and corresponding paracancerous tissue samples. Relationship between miR-193b expression and patients'' age, sex, tumor size, differentiation degree, TNM period, and lymph node metastasis was analyzed. In addition, five-year survival rate was compared between cases with high miR-193b expression and ones with low miR-193b expression. In comparison with paracancerous tissue, miR-193b expression levels were significantly decreased in hepatic cancer tissue (P<0.01). The expression of miR-193b was associated with differentiation degree, TNM period and lymph node metastasis (P<0.05), but not age, sex and tumor size (P>0.05). Five-year survival rate was higher in high miR-193b expression group than low miR-193b expression group (P<0.05). These findings suggest that miR-193b is lowly expressed in hepatic cancer tissue and may serve as a molecular marker for evaluating the degree of tumor malignance and judging the prognosis. |
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| Keywords: | miR-193b hepatic cancer qRT-PCR pathological features survival rate |
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