| 大分割和常规分割放疗联合化疗治疗食管癌术后气管食管沟淋巴结转移的随机对照研究 |
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| 引用本文： | 朱海文,于静萍,汪建林,蒋友芹,裴冬,王坚.大分割和常规分割放疗联合化疗治疗食管癌术后气管食管沟淋巴结转移的随机对照研究[J].中华放射医学与防护杂志,2018,38(7):524-528. |
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| 作者姓名： | 朱海文 于静萍 汪建林 蒋友芹 裴冬 王坚 |
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| 作者单位： | 224001 盐城, 东南大学附属盐城市第三人民医院放疗科,213003 常州, 南京医科大学附属常州市第二人民医院放疗科,213003 常州, 南京医科大学附属常州市第二人民医院放疗科,224001 盐城, 东南大学附属盐城市第三人民医院放疗科,224001 盐城, 东南大学附属盐城市第三人民医院放疗科,213003 常州, 南京医科大学附属常州市第二人民医院放疗科 |
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| 基金项目： | 国家自然科学基金（11705095） |
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| 摘 要： | 目的 探讨大分割放疗（HFR）联合紫杉醇周剂量化疗治疗食管癌术后气管食管沟淋巴结（TGLN）的安全性和疗效。方法 将53例食管癌术后单纯TGLN转移的患者随机抛硬币法分为两组，大分割组25例采用60 Gy/20次放疗，常规分割组28例采用60 Gy/30次放疗，两组患者放疗同时均采用紫杉醇 50 mg周剂量化疗。比较两种不同分割方式对不良反应及预后的影响。结果大分割组和常规分割组患者3~4级放射性食管炎、肺炎发生率分别为44.0%、16.0%和25.0%、7.1%，两组比较差异无统计学意义（P>0.05）。两组近期有效率比较，差异无统计学意义（P>0.05）。淋巴结转移灶直径≤2 cm患者近期有效率高于淋巴结转移灶直径>2 cm的患者（P<0.05）。大分割组和常规分割组中位总生存期（OS）分别为24.2个月（95%CI 16.2~32.1）和11.8个月（95%CI 9.2~14.4），两组比较差异有统计学意义（χ2=5.063，P<0.05）。单因素和多因素分析均显示淋巴结直径和分割方式是影响患者预后的因素（P<0.05）。结论 大分割放疗联合紫杉醇周剂量化疗治疗食管癌术后气管食管沟淋巴结较常规分割提高了患者预后，且治疗并发症未明显增加。
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| 关 键 词： | 食管癌 气管食管沟淋巴结转移 大分割 常规分割 |
| 收稿时间： | 2018/1/14 0:00:00 |
A randomized controlled study of hypofractionated radiotherapy and conventional fractionated radiotherapy combined with chemotherapy in the treatment of postoperative tracheoesophageal groove lymph node metastasis |
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| Zhu Haiwen,Yu Jingping,Wang Jianling,Jiang Youqin,Pei Dong and Wang Jian.A randomized controlled study of hypofractionated radiotherapy and conventional fractionated radiotherapy combined with chemotherapy in the treatment of postoperative tracheoesophageal groove lymph node metastasis[J].Chinese Journal of Radiological Medicine and Protection,2018,38(7):524-528. |
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| Authors: | Zhu Haiwen Yu Jingping Wang Jianling Jiang Youqin Pei Dong and Wang Jian |
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| Institution: | Department of Radiotherapy, Yancheng No.3 People''s Hospital, Affiliated Hospital of Dongnan University, Yancheng 224001, China,Department of Radiotherapy, Changzhou No.2 People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China,Department of Radiotherapy, Changzhou No.2 People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China,Department of Radiotherapy, Yancheng No.3 People''s Hospital, Affiliated Hospital of Dongnan University, Yancheng 224001, China,Department of Radiotherapy, Yancheng No.3 People''s Hospital, Affiliated Hospital of Dongnan University, Yancheng 224001, China and Department of Radiotherapy, Changzhou No.2 People''s Hospital, Affiliated Hospital of Nanjing Medical University, Changzhou 213003, China |
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| Abstract: | |
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| Keywords: | Esophageal cancer Tracheoesophageal groove lymph node metastasis Hypofractioned radiotherapy Conventional fractioned radiotherapy |
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