结直肠癌化疗药物基因多态性研究进展

药物化疗是结直肠癌抗肿瘤治疗的重要手段，氟尿嘧啶类、铂类、伊立替康是结直肠癌化疗的常规用药。但在临床中，肿瘤患者个体之间存在化疗效果和不良反应的差异，这种差异与参与药物代谢、转运和失活的多种蛋白密切相关，其相应的基因多态性是导致个体之间化疗反应差异的重要物质基础，因此明确这些基因多态性位点对于实现肿瘤的个体化治疗、提高化疗效果具有重要意义。结合国内外药物基因组学最新的研究进展，系统综述了结直肠癌主要的化疗药物相关基因多态性与结直肠癌化疗敏感性研究的关系，以期为结直肠癌个体化化疗提供依据。

Research progress on gene polymorphism of chemotherapy drugs for colorectal cancer

Chemotherapy plays an important role in the treatment of colorectal cancer, with fluorouracil platinum and irinotecan being the common drugs. However, patients respond differently to the same drugs in clinical, and the difference are closely related with involved in drug metabolism, transportation, and orinactivation of a variety of proteins. The important material base chemotherapy response differences between individuals, thus it is important to clear these gene polymorphism to realize individualized treatment and improve the efficacy of cancer chemotherapy. The relationship between gene polymorphisms and chemosensitivity for colorectal cancer according to the latest studies is reviewed in this paper, which may provide evidences for the individualized chemotherapy for colorectal cancer.