新疆维吾尔族、汉族抗结核药物性肝损伤患者IL-10分泌水平的研究

目的 探讨汉族、维吾尔族抗结核药物诱导的肝损伤（ATDLI）患者IL-10分泌量，比较两民族之间存在的差异。方法 选取新疆维吾尔自治区胸科医院、石河子大学医学院第一附属医院确诊的ATDLI患者。采用双抗体夹心ELISA测定患者IL-10的分泌量。比较两个民族以及两个民族不同性别、不同肝损伤程度的患者血清IL-10的表达量。结果 共收集ATDLI汉族组患者100例，维吾尔族组患者135例。维吾尔族组ATDLI患者IL-10分泌量（56.30±17.24）pg/mL]高于汉族组（45.81±11.04）pg/mL]，差异有统计学意义（P<0.0001）。汉族轻度、中度及重度肝损伤组患者血清IL-10水平分别为（44.73±9.10）、（47.39±10.58）、（49.52±13.21）pg/mL；维吾尔族轻度、中度及重度肝损伤组患者血清IL-10水平分别为（52.30±15.24）、（56.84±13.71）、（58.62±14.38）pg/mL。组间比较显示，IL-10的分泌量汉族、维吾尔族中重度肝损伤组患者均高于轻度肝损伤组患者（均P<0.05）。结论 ATDLI患者IL-10分泌量随肝损伤程度的加重而升高。ATDLI患者IL-10分泌量维吾尔族高于汉族。

Secretion level of interleukin-10 in Han and Uyghur nationality patients with anti-tuberculosis drug-induced liver injury

Objective To evaluate the secretion level of interleukin-10 (IL-10) in Han and Uyghur nationality patients with anti-tuberculosis drug-induced liver injury(ATDLI), and compare the difference between two nationalities. Methods Patients who were diagnosed with ATDLI in Chest Hospital of Xinjiang Uyghur Autonomous Region and the First Affiliated Hospital of Medical College of Shihezi University were selected. Secretion level of IL-10 in patients was detected by double antibody sandwich ELISA. Expression level of serum IL-10 in patients of two nationalities, different genders, and different extent of liver injury of two nationalities were compared. Results A total of 100 ATDLI Han and 135 Uyghur nationality patients were collected. The secretion level of IL-10 in Uyghur nationality ATDLI patients was higher than that in Han nationality patients (56.30±17.24]pg/mL VS45.81±11.04]pg/mL, P<0.0001). Serum levels of IL-10 in patients with mild, moderate, and severe liver injury in Han nationality patients were (44.73±9.10)pg/mL, (47.39±10.58) pg/mL, and(49.52±13.21)pg/mL, respectively; in Uyghur nationality patients were (52.30±15.24)pg/mL, (56.84±13.71)pg/mL, and (58.62±14.38)pg/mL, respectively. Group comparison showed that the secretion level of serum IL-10 of patients with moderate and severe liver injury in Han and Uyghur nationalities were both higher than that in patients with mild liver injury (both P<0.05). Conclusion Secretion level of IL-10 in patients with ATDLI increases with the severity of liver injury. Secretion level of IL-10 in Uyghur nationality ATDLI patients is higher than that in Han nationality ATDLI patients.