特利加压素致皮肤坏死的不良反应分析

目的 探讨特利加压素致皮肤坏死不良反应的发生规律、危险因素等，为临床合理使用该药提供参考。方法 报道1例特利加压素所致的皮肤坏死，并检索相关文献，对报道的案例进行分类统计分析。结果 特利加压素引起的皮肤坏死以男性为主（76.67%），年龄主要分布在50岁以上（73.33%），不良反应高发时间为用药前5 d（83.33%），以躯干、四肢多见。低血容量、肥胖、酒精性肝病肝硬化、合并使用血管活性药物等可能为特利加压素引起皮肤缺血的高危因素。结论 临床使用中应重视特利加压素引起皮肤坏死的不良反应，应用过程要密切关注，及早发现，及早处理。

Analysis of Adverse Reactions of Terlipressin on Skin Necrosis

OBJECTIVE To study the general regularity and risk factors of adverse drug reactions to skin necrosis induced by terlipressin, to provide reference for the rational use of drug in clinical. METHODS Reported one case of skin necrosis caused by terlipressin, searched related literature and statistical analysis. RESULTS The skin necrosis caused by terlipressin was mainly in males(76.67%) and over 50 years old(73.33%), the time of high incidence of adverse reactions was 5 d before medication(83.33%), mainly in trunk and limbs. Low blood volume, obesity, alcoholic liver cirrhosis, combined use of vasoactive drugs may high risk factors of skin ischemia caused by terlipressin. CONCLUSION The clinical use of terlipressin should pay attention to the adverse reactions caused by necrosis of the skin, and pay close attention to the application process, early detection and early treatment.