抗肿瘤中药纳米给药系统的研究进展

纳米给药系统是靶向递送抗肿瘤药物的理想载体，它可以极大地提高抗肿瘤药物的治疗效果，明显减轻系统毒性，在替代传统化疗方面极具应用前景。在中医药理论指导下，抗肿瘤中药有着许多化疗药物难以比拟的多组分协同优势。但是，受制于难溶性成分的吸收障碍以及体内的无选择性分布，抗肿瘤中药的治疗效果还有很大的提升空间。近年来，通过对纳米给药系统和中药多组分在抗肿瘤领域优势的有机整合，多种中药纳米给药系统见于报道：在改善药物的生物利用度，提高药物的靶向能力，增加药物体内外稳定性，智能调节组分释放以及增效减毒方面优势显著，大量的研究实例丰富了中药制剂现代化的研究策略，也为今后的临床应用提供了大量的科研数据，本文以靶向策略方式为切入点，综述了近年来中药纳米给药系统的研究进展。

Review on Antitumor Nano-sized Drug Delivery System Based on Traditional Chinese Medicine

Nano-sized drug delivery system is an ideal carrier for the delivery of antitumor drugs. It is able to greatlyimprove the therapeutic effect and obviously reduce the systemic toxicity. It presents promising potential as an alternativetreatment to the traditional chemotherapy. Based on the theory of traditional Chinese medicine (TCM), the antitumormulticomponent medicine possesses a lot of advantages over chemotherapy drugs. However, TCM still faces severalissues due to the poor absorption of insoluble components and the non-selective biodistribution. Recently, due to therational combination of nano-sized drug delivery system and multicomponent TCM in the field of antitumor study, avariety of nano-drug system based on TCM have been reported, which exhibited lots of advantages such as improvedbioavailability, enhanced tumor targeting, optimized stability in vitro and in vivo, smart drug release and synergisticantitumor effects. These studies enrich the modernization of TCM, and offer a feasibility of antitumor treatment forclinical application. This review focused on the research progress of nano-sized drug delivery system based on TCM foranticancer therapy in the perspective of target manner, and gave out our views on the current situation of TCMpharmaceutics.