运动疲劳导致大鼠焦虑并伴有海马CA1区θ节律活动增强

目的:研究运动疲劳对大鼠焦虑情绪的影响,观测海马CA1区场电位θ节律震荡的变化,揭示运动疲劳引发不良情绪效应的可能神经电生理机制.方法:雄性Wistar大鼠随机分为对照组(control)和运动疲劳组(exercise training,ET),采用反复7d力竭跑台训练方式建立疲劳模型.行为学实验采用高架十字迷宫观察大...

Exercise fatigue results in anxiety and enhances theta rhythm in CA1 of hippocampus in rats

Objective:To study the effect of exercise fatigue on the anxiety of rats,observe the changes of theta rhythm in hippocampal CA1 region,and reveal the possible neuro-electrophysiological mechanism of exercise fatigue inducing adverse emotional effects.Methods:Male Wistar rats were randomly divided into control group(control)and exercise training group(ET).The fatigue model was established by repeated 7 dayst’readmill exhausted exercise.Elevated plus maze test was employed to detect the rats’anxiety-like behaviors after the exercise modeling.Subsequently,CA1 region multi-channel local field potentials(LFP)recording in vivo.Comparing the difference of theta rhythm activity in hippocampus between two groups of rats.Results:In elevated plus maze test,compared with control group,the entry times to the open arm was significantly decreased compared with ET group(P<0.05),so as the time of rats staying in the open arm(P<0.01);And the time ET group staying in closed arm was significantly longer than control group(P<0.01).The electrical signal record of theta rhythm in the hippocampal CA1 region showed that the peak power of the ET group was significantly higher than that of the control group(P<0.05).However,we did not find any significant difference between two groups on theta frequency(P>0.05).Conclusion:After exercise fatigue,rats’exploratory behaviors decrease,anxiety-like behaviors increase,and theta rhythm in hippocampal CA1 region increases.This kind of anxiety is related to the change of theta rhythm,suggesting that the enhancement of theta rhythm may be one of the electrophysiological mechanisms of anxiety and other bad emotions caused by exercise fatigue.