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Blastic NK-cell lymphomas (agranular CD4+CD56+ hematodermic neoplasms): a review |
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| Authors: | Petrella Tony Bagot Martine Willemze Rein Beylot-Barry Marie Vergier Béatrice Delaunay Michèle Meijer Chris J L M Courville Philippe Joly Pascal Grange Florent De Muret Anne Machet Laurent Dompmartin Anne Bosq Jacques Durlach Anne Bernard Philippe Dalac Sophie Dechelotte Pierre D'Incan Michel Wechsler Janine Teitell Michael A |
| Affiliation: | Centre de Pathologie, Department of Pathology, Centre Hospitalo-Universitaire, Dijon, France. |
| Abstract: | Blastic natural killer (NK) cell lymphoma (also termed CD4+CD56+ hematodermic neoplasm) is a recently described entity, with the first case reported in 1994. It was suggested initially that the disease originates from NK cells. Since 1994, single cases and a few small series have been published. In this review, data from the literature and a series of 30 cases from the French and Dutch study groups on cutaneous lymphomas are discussed. The major clinical, histopathologic, and phenotypic aspects of the disease and diagnostic criteria and data suggesting a plasmacytoid dendritic cell origin for the tumor cells are provided. |
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