妊娠高血压疾病血脂指标的变化

目的分析妊娠高血压疾病的血脂代谢特点，了解血脂代谢紊乱和妊娠高血压疾病的关系。方法选取孕周为37～41周的健康妊娠孕妇60例（正常妊娠组），妊娠高血压疾病孕妇90例（妊娠高血压疾病组），正常未孕女性60例（未孕组），比较3个组的三酰甘油（TG）、总胆固醇（TC）、高密度脂蛋白-胆固醇（HDL-C）、低密度脂蛋白-胆固醇（LDL-C）、载脂蛋白-A（Apo-A）、载脂蛋白-B（Apo-B）及脂蛋白a（Lpa）之间的差异。同时将90例妊娠高血压疾病孕妇按病程分级分为妊娠高血压组30例、轻度子痫前期组30例及重度子痫前期组30例共3个组，并比较不同分级的妊娠高血压疾病孕妇血脂的变化，分析血脂异常程度与妊娠高血压疾病严重程度的关系。结果（1）未孕组、正常妊娠组及妊娠高血压疾病组间TC、TG、HDL-L、LDL-L、Apo-A及Apo-B水平差异有统计学意义（P＜0．05）；而3个组间Lpa水平差异无统计学意义（P＞0．05）。（2）在不同病程妊娠高血压疾病中，妊娠高血压组、轻度子痫前期组及重度子痫前期组3个组的TG、LDL-C、Apo-B水平比较差异有统计学意义（P＜0．05），而TC、HDL-L、Apo-A及Lpa各组之间差异无统计学意义（P＞0．05）。结论妊娠高血压疾病的发生可能与孕期血脂代谢紊乱相关，血脂异常程度越高，发生严重妊娠高血压疾病的可能性就越大，故加强血脂监测，早期进行干预并纠正血脂紊乱以保证母婴健康。

Analysis of relationship between serum lipids and hypertensive disorders in pregnancy

Objective To analyze the characteristics of lipid metabolism in pregnant women with hypertensive disorders .Methods A total of 60 cases of healthy pregnant women in the gestational age of 37-41 weeks （healthy pregnancy group） ,90 cases of pregnant women hypertensive disorders （hypertensive disorders group） and 60 healthy unpregnant women（unpregnant group） were enrolled ,and compared for blood levels of triglyceride （TG） ,total cho-lesterol（TC） ,high density lipoprotein-cholesterol（HDL-C） ,low density lipoprotein-cholesterol（LDL-C） ,apolipopro-tein-A（Apo-A） ,apolipoprotein-B（Apo-B） and lipoprotein a（Lpa） .The 90 cases of pregnant women with hypertensive disorders were divided into three groups ,including gestational hypertension group（30 cases） ,mild preeclampsia group （30 cases） ,severe preeclampsia group（30 cases） ,and levels of blood lipids were compared between each group to i-dentify the relationship between lipids and hypertensive disorders in pregnancy .Results （1）Levels of TC ,TG ,HDL-C ,LDL-C ,Apo-A and Apo-B were statistically different among healthy pregnancy group ,hypertensive disorders group and unpregnant group（P〈0 .05） ,while Lpa levels were not statistically different （P〉 0 .05） .（2） Levels of TG ,LDL-C and Apo-B were significantly different among gestational hypertension group ,mild preeclampsia group and severe preeclampsia group（P〈0 .05） ,while levels of TC ,HDL-C ,Apo-A and Lpa were not significantly different （P〉 0 .05） .Conclusion Hypertensive disorders in pregnancy might be correlated with pregnancy-related dyslipi-demia .The onset risk of hypertensive disorders in pregnancy could be increased with the elevation of the severity of dyslipidemia .Enhancing lipid monitoring ,early intervention of dyslipidemia could ensure maternal and child health .