The effect of delta-sleep-inducing peptide on the Ca-transporting system of the sarcoplasmic reticulum and activity of the myocardial antioxidant enzymes |
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| Authors: | T G Sazontova N E Golantsova S N Kolmykova M I Arkhangelskaya I L Kosharskaya Yu V Arkhipenko |
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| Institution: | (1) Department of Pathophysiology of Adaptation Processes, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow;(2) Laboratory of Experimental Cardiology, P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | It is demonstrated that immobilization stress against the background of lowered catalase activity impairs the function of
the sarcoplasmic reticulum Ca pump, particularly at high Ca2+ levels. the membranes of intracellular Ca2+ depots are destroyed much more rapidly than in the control, which results in Ca2+ release. Administration of delta sleep-inducing peptide to control animals results in a 30% increase in catalase activity
for an unchanged level of superoxide dismusase and markedly improves the function of the Ca-transporting system at elevated
levels of free Ca2+. A long-term stress after administration of the peptide not only causes no damage to the Ca-transporting system but actually
increases its efficiency (compared with the control) at a high catalase level.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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3, pp. 248–251, March, 1996
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences |
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| Keywords: | delta sleep-inducing peptide Ca pump sarcoplasmic reticulum superoxide dismutase myocardium |
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