黄芪-当归药对益气活血药理作用研究进展

黄芪-当归药对(AA)为针对气血俱病这一证候特点而设的基础药对,李东垣之当归补血汤(DBT)即由AA组成,以补气生血为要,主治气虚血亏、血热诸证,因其组方精炼、疗效显著而颇受医家青睐.然而,古籍所载AA在不同组方中有多种配伍比例,其功效主治也各不相同.现代研究表明DBT亦有益气活血之效,且课题组前期研究发现AA在总量3...

Research Progress on Pharmacological Effect of Astragali Radix-Angelicae Sinensis Radix on Invigorating Qi and Activating Blood

Astragali Radix-Angelicae Sinensis Radix(AA)is a basic pair of drugs mainly targeting the syndrome characteristics of Qi and blood diseases.LI Dong-yuan’s Danggui Buxuetang(DBT)is composed of AA,which is mainly used to tonify Qi and generate blood,with main indications of Qi deficiency and blood deficiency,blood heat and so on.It is favored by doctors because of its refined prescription and remarkable curative effect.However,there are many compatibility ratios of AA in different prescriptions in ancient books,and their efficacy and indications are also slightly different.This research showed that DBT also had the effect of invigorating Qi and activating blood,and the previous study of the group showed that 3∶1 compatibility ratio of the two herbs in the total amount of 36 g had more obvious effect of invigorating Qi and activating blood.By consulting the relevant literature,it was found that the drug pair had a certain effect of invigorating Qi and activating blood in various compatibility ratios such as 1∶1,3∶1,1∶5,3∶2,2∶1,5∶1.The corresponding pharmacological effect mainly included regulating the energy metabolism of substances,regulating immune function,reducing blood viscosity,anti-oxidation stress,anti-inflammation,lowering blood lipids,lowering blood sugar,protecting heart function,protecting blood vessel wall,intervening angiogenesis,fighting against organ tissue fibrosis and so on.Regardless of the AA single-medicine’s activating blood effect and the theory thatQi circulation leads to blood circulationor the drug pair’s manifestation in modern pharmacological effects,all of these have confirmed that AA’s effect of invigorating Qi and activating blood does exist,and the difference of action performance caused by different ratios of AA is closely related to dosage and proportion,which needs further study.Based on the study focusing on the effect of tonifying Qi and generating blood,it is easy to ignore the effect of invigorating Qi and activating blood,which limits the clinical application of the latter.Therefore,the tonifying Qi and activating blood circulation effect of the drug pair is reviewed in this paper,so as to provide a theoretical basis for its clinical rational drug use and related research.