Distinct features of distant metastasis and lymph node stage in lung adenocarcinoma patients with epidermal growth factor receptor gene mutations |
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| Authors: | Yasunori Enomoto Kazuto Takada Eri Hagiwara Eiji Kojima |
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| Institution: | 1. Division of Respiratory and Allergy Medicine, Komaki City Hospital, Komaki, 1-20, Johbushi, Komaki City 485-8520, Japan;2. Division of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, 6-16-1 Tomioka-Higashi, Kanazawa-ku, Yokohama City 236-0051, Japan;1. Department of Respiratory Medicine & Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan;2. Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan;3. Immunoregulations Section, Laboratory of Molecular Biology and Immunology, National Institute on Aging, Baltimore, MD, USA;1. Department of Thoracic and Cardiovascular Surgery, Yonsei University, College of Medicine, Seoul, Republic of Korea;2. Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea;3. Department of Laboratory Medicine, Yonsei University, College of Medicine, Seoul, Republic of Korea;1. Division of Thoracic Oncology, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka 411-8777, Japan;2. Division of Thoracic Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka 411-8777, Japan;3. Division of Diagnostic Radiology, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo Nagaizumi-cho Sunto-gun, Shizuoka 411-8777, Japan;1. Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan;2. First Department of Internal Medicine, Kurume University School of Medicine, 67 Asahi-machi, 830-0011 Kurume, Japan;3. Department of Pulmonary Medicine, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan;1. Department of Thoracic Surgery, Nara Prefectural Nara Hospital, Japan;2. Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Japan;1. Division of Pulmonary Medicine, Infectious Diseases and Oncology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan;2. Department of Advanced Preventive Medicine for Infectious Disease, Tohoku University, Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai 980-8575, Japan;3. Internal Medicine II, Faculty of Medicine, Oita University, Oita, Japan;4. Center for Infectious Diseases, Nara Medical University, Nara, Japan;5. Fukujuji Hospital, Japan Tuberculosis Association, Tokyo, Japan |
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| Abstract: | BackgroundThe influence of epidermal growth factor receptor (EGFR) mutation status on distant and lymph node metastasis is not fully understood.MethodsNinety-five consecutive patients with stage IV lung adenocarcinoma, who had been examined for the EGFR mutation status, were retrospectively analyzed with regard to numbers of distant metastasis and clinical stage of lymph node metastasis at the time of diagnosis.ResultsWhile EGFR mutation status did not influence the presence or absence of distant metastasis in the lung, brain, or liver, patients with EGFR mutations demonstrated a significantly greater number of metastatic lesions in the lung (median: 85 vs. 4, P=0.01) and the brain (11 vs. 3.5, P=0.04). On the other hand, patients with EGFR mutations showed a significantly lower lymph node staging (P<0.01).ConclusionThe presence of EGFR mutations in patients with lung adenocarcinoma correlates with lower lymph node stage and a greater number of metastatic lesions in the lung and brain. |
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