补肾活血法对系统性红斑狼疮合并动脉粥样硬化小鼠免疫功能和组织病理学的影响

目的:观察补肾活血法对系统性红斑狼疮(SLE)合并动脉粥样硬化模型小鼠免疫功能和主动脉斑块的影响.方法:8周龄大雌性载脂蛋白E基因敲除小鼠(ApoE-/-mice)45只,给予一次性腹腔注射降植烷(pristane)0.5ml,继续喂养16周后,小鼠随机分为中药治疗组、西药治疗组和模型组3组各15只,以同周龄C57BL...

Effect of Kidney-tonifying and Blood-activating Therapy on Immune Function and Histopathology of Systemic Lupus Erythematosus Mice with Atherosclerosis

Objective:To observe the effect of kidney-tonifying and blood-activating method on immune function and aortic plaque in mice with systemic lupus erythematosus and atherosclerosis.Methods:Forty-five eight-week-old female apolipoprotein E-gene knockout mice were intraperitoneally injected with 0.5ml norphytane.After 16 weeks of feeding,the mice were randomly divided into three groups,the Chinese medicine treatment group,the Western medicine treatment group and the Model group,15 mice in each group.C57BL/6 mice of the same age were used as normal Control group.Results:Compared with the Control group,the levels of urea nitrogen,creatinine,cholesterol and triglyceride,immunoglobulin IgG in the model group were significantly increased.The level of complement C3 was decreased,the spleen weight and proteinuria were increased,and the aorta had larger plaque formation.Both the Chinese medicine treatment group and the Western medicine treatment group could improve renal function,albuminuria and splenomegaly,and there was no significant difference between the two groups.The Chinese medicine treatment group was better than the Western medicine treatment group in lowering cholesterol,triglyceride levels and IgG levels.Compared with the Western medicine treatment group,the Chinese medicine treatment group could significantly improve the scope of aortic atherosclerotic plaques.Conclusions:Compared with the Western medicine therapy,kidney-tonifying and blood-activating therapy has more obvious effects on lowering blood lipid,improving the level of immunoglobulin and arterial plaque in SLE with atherosclerosis model mice.