外泌体与变应性鼻炎的相关研究进展

变应性鼻炎，是特应性个体接触致敏原后由 IgE介导的鼻黏膜慢性炎症反应性疾病，以鼻痒、喷嚏、鼻分泌亢进等为其主要特点。近年来随着社会工业化进展，环境改变，中国变应性鼻炎患病率呈上升趋势。外泌体是近几十年新发现的一种纳米级的囊泡，内含蛋白质、核酸等物质，在细胞间沟通发挥着重要作用。现就近些年关于外泌体的相关基础研究进行总结，重点讨论其在变应性鼻炎中的作用机制，同时总结外泌体在变应性鼻炎治疗的潜在价值。

Research progress of exosomes and allergic rhinitis

Allergic rhinitis is a chronic inflammatory reaction disease of nasal mucosa mediated by IgE after allergic individuals con.tact with allergens. Its main characteristics are nasal itching, sneezing and nasal hypersecretion. In recent years, with the progress of so.cial industrialization and environmental changes, the prevalence of allergic rhinitis in China is on the rise. Exosomes are nano vesiclesnewly discovered in recent decades. They contain proteins, nucleic acids and other substances, and play an important role in intercellu.lar communication. This review summarizes the relevant basic research on exosomes in recent years, focuses on its mechanism in aller.gic rhinitis, and summarizes the potential value of exosomes in the treatment of allergic rhinitis.