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Multiple gastrointestinal stromal tumors and pheochromocytoma in a patient with von Recklinghausen's disease
Authors:Beyza Ozcinar  Nihat Aksakal  Orhan Agcaoglu  Mustafa Tukenmez  Ibrahim A. Ozemir  Umut Barbaros  Nese Colak  Yesim Erbil
Affiliation:1. Istanbul University, Istanbul Medical Faculty, General Surgery Department, Capa, Istanbul, Turkey;2. Istanbul University, Istanbul Medical Faculty, Internal Medicine Department, Turkey
Abstract:INTRODUCTIONNeurofibromatosis type 1 is a genetic disease characterized by neoplastic and non neoplastic disorders involving tissues of neuroectodermal and mesenchymal origin. Herein, we present a case with von Recklinghausen's disease, right adrenal heochromocytoma and multiple gastrointestinal stromal tumors.PRESENTATION OF CASEA forty-eight year old male patient was admitted to our Emergency Department with melena. His physical examination revealed multiple neurofibromas all over the skin, kyphosis, multiple cafe au lait spots and Lisch nodules on the eye and, melena on digital rectal examination. Abdominal computerized tomography scan showed a mass on right adrenal gland and multiple soft tissue mass lesions between distal part of pancreas and small bowel. Adrenal mass was determined as a pheochromocytoma and small bowel lesions were verified as stromal tumors.DISCUSSIONIn patients with NF1, pheochromocytomas and GISTs are well known neoplasms seen with increased incidence than the general population.CONCLUSIONIn patients with NF1, any symptoms with other systems should be managed carefully for underlying malignity.
Keywords:Neurofibromatozis type 1   Von Recklinghausen''s disease   Gastrointestinal stromal tumor   Pheochromocytoma
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