The Absolute Monocyte and Lymphocyte Prognostic Index for Patients With Diffuse Large B-Cell Lymphoma Who Receive R-CHOP |
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Authors: | Nicolas Batty Elham Ghonimi Lei Feng Luis Fayad Anas Younes Maria Alma Rodriguez Jorge Enrique Romaguera Peter McLaughlin Felipe Samaniego Larry W Kwak Fredrick B Hagemeister |
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Institution: | 1. Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka 513-8670, Japan;2. Department of Biotechnology, College of Life Sciences, Ritsumeikan University, Kusatsu 525-8577, Japan;3. Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606-8501, Japan;4. Faculty of Pharmaceutical Sciences, Osaka University of Pharmaceutical Sciences, Takatsuki 569-1094, Japan |
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Abstract: | BackgroundThe baseline absolute monocyte count and absolute lymphocyte count were used to generate a prognostic index (the AMLPI) for survival in diffuse large B-cell lymphoma (DLBCL).MethodsData from 245 patients with DLBCL who were treated with standard R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulfate, prednisone) were reviewed. By using the values previously reported for the AMLPI, its prognostic value was examined in our population.ResultsAfter a median follow-up of 22 months for censored observations, the 3-year progression-free survival (PFS) rates for the international prognostic index (IPI) 0-2 and 3-5 risk groups were 73% and 58%, respectively (P = .0004); comparable overall survival (OS) rates were 88% and 68%, respectively (P < .0001). For patients with IPI scores of 0-2, 1-year PFS rates for AMLPI low-, intermediate-, and high-risk groups were 92%, 89%, and 80%, respectively (P = .022); comparable 1-year OS rates were 96%, 95%, and 80%, respectively (P = .049). By multivariate analysis, with the adjustment of IPI in the model, AMLPI effects (low- vs. high-risk groups) on PFS and OS rates were significant, with P = .046 (hazard ratio HR] 0.402 95% CI, 0.164-0.986] and P = .052 (HR 0.325 95% CI, 0.104-1.011]), respectively.ConclusionsThe absolute monocyte and lymphocyte counts prognostic index (the AMLPI) may add prognostic value beyond that of the IPI for patients with DLBCL who receive R-CHOP. |
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